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1071979-62-8

L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1071979-62-8 Structure

  • Basic information

    1. Product Name: L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-
    2. Synonyms: 1071979-62-8;L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-
    3. CAS NO:1071979-62-8
    4. Molecular Formula: C30H42N6O5S
    5. Molecular Weight: 598.767
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1071979-62-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-(1071979-62-8)
    11. EPA Substance Registry System: L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-(1071979-62-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1071979-62-8(Hazardous Substances Data)

1071979-62-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1071979-62-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,1,9,7 and 9 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1071979-62:
(9*1)+(8*0)+(7*7)+(6*1)+(5*9)+(4*7)+(3*9)+(2*6)+(1*2)=178
178 % 10 = 8
So 1071979-62-8 is a valid CAS Registry Number.

1071979-62-8Relevant articles and documents

INHIBITORS OF IAP

-

, (2013/07/19)

Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula (I): wherein R1,R2,R3,R4,R5 and R6 are as described herein.

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)

Flygare, John A.,Beresini, Maureen,Budha, Nageshwar,Chan, Helen,Chan, Iris T.,Cheeti, Sravanthi,Cohen, Frederick,Deshayes, Kurt,Doerner, Karl,Eckhardt, S. Gail,Elliott, Linda O.,Feng, Bainian,Franklin, Matthew C.,Reisner, Stacy Frankovitz,Gazzard, Lewis,Halladay, Jason,Hymowitz, Sarah G.,La, Hank,Lorusso, Patricia,Maurer, Brigitte,Murray, Lesley,Plise, Emile,Quan, Clifford,Stephan, Jean-Philippe,Young, Shin G.,Tom, Jeffrey,Tsui, Vickie,Um, Joanne,Varfolomeev, Eugene,Vucic, Domagoj,Wagner, Andrew J.,Wallweber, Heidi J. A.,Wang, Lan,Ware, Joseph,Wen, Zhaoyang,Wong, Harvey,Wong, Jonathan M.,Wong, Melisa,Wong, Susan,Yu, Ron,Zobel, Kerry,Fairbrother, Wayne J.

, p. 4101 - 4113 (2012/06/30)

A series of compounds were designed and synthesized as antagonists of cIAP1/2, ML-IAP, and XIAP based on the N-terminus, AVPI, of mature Smac. Compound 1 (GDC-0152) has the best profile of these compounds; it binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with Ki values of 28, 14, 17, and 43 nM, respectively. These compounds promote degradation of cIAP1, induce activation of caspase-3/7, and lead to decreased viability of breast cancer cells without affecting normal mammary epithelial cells. Compound 1 inhibits tumor growth when dosed orally in the MDA-MB-231 breast cancer xenograft model. Compound 1 was advanced to human clinical trials, and it exhibited linear pharmacokinetics over the dose range (0.049 to 1.48 mg/kg) tested. Mean plasma clearance in humans was 9 ± 3 mL/min/kg, and the volume of distribution was 0.6 ± 0.2 L/kg.

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