1071983-03-3Relevant academic research and scientific papers
Reductive ligation mediated one-step disulfide formation of S -nitrosothiols
Zhang, Jiming,Li, Sheng,Zhang, Dehui,Wang, Hua,Whorton, A. Richard,Xian, Ming
supporting information; experimental part, p. 4208 - 4211 (2010/11/17)
A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.
Fast reductive ligation of S-nitrosothiols
Wang, Hua,Xian, Ming
supporting information; experimental part, p. 6598 - 6601 (2009/03/12)
(Chemical Equation Presented) Nitroso knows: A process has been developed which converts unstable S-nitrosothiols into stable sulfenamide analogues (see scheme).Reductive ligation proceeds rapidly in mixed organic solvent/water systems to give high yields. By applying this reaction, an efficient strategy for detecting S-nitrosylation in proteins and other biological systems is envisioned.
