1071983-17-9Relevant academic research and scientific papers
Total synthesis of the leucetta-derived alkaloid calcaridine a
Koswatta, Panduka B.,Sivappa, Rasapalli,Dias, H. V. Rasika,Lovely, Carl J.
experimental part, p. 2970 - 2982 (2010/03/25)
A biomimetically guided total synthesis of the Leucettaderived aminoimidazole alkaloid, calcaridine A, is described. The synthesis relies on position selective metalations of a 4,5-diiodoimidazole derivative to provide a tetrasubstituted imidazole. Subjec
Total synthesis of (±)-calcaridine A and (±)-epi-calcaridine A
Koswatta, Panduka B.,Sivappa, Rasapalli,Rasika Dias,Lovely, Carl J.
supporting information; experimental part, p. 5055 - 5058 (2009/05/31)
(Chemical Equation Presented) The first total synthesis of the Leucetta alkaloid calcaridine A is described based on a biosynthetic postulate. Application of an oxidative rearrangement of a 4,5-disubstituted imidazole leads to the formation of both calcaridine A and epi-calcaridine A. An X-ray crystal structure determination on the latter has allowed the assignment of the relative configuration of the epimeric natural product and calcaridine A by extrapolation.
