1071998-88-3Relevant academic research and scientific papers
Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups
Anh?user, Lea,Muttach, Fabian,Rentmeister, Andrea
, p. 449 - 451 (2018)
Methyltransferases are powerful tools for site-specific transfer of non-natural functional groups from synthetic analogs of their cosubstrate S-adenosyl-l-methionine (AdoMet). We present a new class of AdoMet analogs containing photo-caging (PC) groups in their side chain, enzymatic transfer of PC groups by a promiscuous DNA MTase as well as light-triggered removal from the target DNA. This strategy provides a new avenue to reversibly modulate the functionality of DNA at MTase target sites.
Orthogonal photocleavage of a monochromophoric linker
Kammari, Laxminarayana,Solomek, Tomas,Ngoy, Bokolombe Pitchou,Heger, Dominik,Klan, Petr
supporting information; experimental part, p. 11431 - 11433 (2010/10/03)
The 4-acetyl-2-nitrobenzyl moiety, substituted in both benzylic and phenacyl positions with leaving groups, has been proposed as a monochromophoric photocleavable linker. The attached groups can be disconnected selectively and orthogonally upon irradiation.
