1071998-95-2Relevant academic research and scientific papers
Organocatalytic sequential α-aminoxylation and cis-Wittig olefination of aldehydes: Synthesis of enantiopure γ-butenolides
Devalankar, Dattatray A.,Chouthaiwale, Pandurang V.,Sudalai, Arumugam
experimental part, p. 240 - 244 (2012/06/04)
A short route to enantiopure γ-butenolides (up to 99% ee) has been developed from readily available starting materials. The strategy involves a sequential organocatalytic α-aminoxylation followed by cis-Wittig olefination of aldehydes. The utility of this protocol has been demonstrated in the asymmetric synthesis of trans-(+)-cognac lactone with high enantiomeric purity.
Asymmetric, organocatalytic, three-step synthesis of γ-hydroxy-(E)- α,β-unsaturated sulfones and esters
Petersen, Kimberly S.,Posner, Gary H.
supporting information; experimental part, p. 4685 - 4687 (2009/05/26)
(Chemical Equation Presented) Efficient and enantiocontrolled synthesis of γ-hydroxy-α,β-unsaturated sulfones and esters are reported through the reaction of enantioenriched a-selenyl aldehydes with EWG-stabilized carbanions and then a one-pot selenide ox
