1072-12-4

Basic information

• Product Name: GLYOXAL DITHIOSEMICARBAZONE
• Synonyms: GLYOXAL DITHIOSEMICARBAZONE;GLYOXAL BIS(THIOSEMICARBAZONE);1,2-Ethanedione bis(aminomercaptomethylenehydrazone);1,2-Ethanedione bis(thiosemicarbazone);1,2-Ethanedione bisthiosemicarbazone;3,3'-(1,4-Diaza-1,3-butadiene-1,4-diyl)bis(isothiourea);Nsc22181;Hydrazinecarbothioamide,2,2'-(1,2-ethanediylidene)bis-
• CAS NO: 1072-12-4
• Molecular Formula: C₄H₈N₆S₂
• Molecular Weight: 204.28
• Mol File: 1072-12-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 384.6°Cat760mmHg
• Flash Point: 186.4°C
• Appearance: /
• Density: 1.61g/cm³
• Vapor Pressure: 4.03E-06mmHg at 25°C
• Refractive Index: 1.75
• CAS DataBase Reference: GLYOXAL DITHIOSEMICARBAZONE(CAS DataBase Reference)
• NIST Chemistry Reference: GLYOXAL DITHIOSEMICARBAZONE(1072-12-4)
• EPA Substance Registry System: GLYOXAL DITHIOSEMICARBAZONE(1072-12-4)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• Hazardous Substances Data: 1072-12-4(Hazardous Substances Data)

Usage

General Description

Glyoxal dithiosemicarbazone, also known as thiosemicarbazone, is a compound used in various chemical and pharmaceutical applications. It is a chelating agent that forms stable complexes with a variety of metals, making it useful in analytical and industrial processes such as metal ion detection and removal. It also exhibits antioxidant and antimicrobial properties, making it a potential candidate for medical and cosmetic formulations. Additionally, glyoxal dithiosemicarbazone has been studied for its potential antitumor and antiviral activities, suggesting its potential in the development of new drugs. However, further research is needed to fully understand its biological and chemical properties and its potential applications.

InChI:InChI=1/C4H8N6S2/c5-3(11)9-7-1-2-8-10-4(6)12/h1-2H,(H3,5,9,11)(H3,6,10,12)/b7-1-,8-2-

Upstream product

• 79-19-6 thiosemicarbazide 
• 53629-29-1 1,3-diethyl-4,5-dihydroxyimidazolidin-2-one 
• 131543-46-9 Glyoxal 

Relevant articles and documents

IMAGING AGENTS

The present invention provides certain thiosemicarbazone metal complexes which have advantageous properties in medical imaging. The thiosemicarbazone metal complexes can be safely and easily produced in real time, administered quickly after production, readily cross the blood-brain barrier, and may utilize a number of different radionuclides.

Unexpected Formation of Thioglycolurils Precursors

Unexpectedly, nitrosation of 5,7-dialkyl-3-thioxoperhydroimidazo[4,5-e]-1,2,4-triazine-6-ones(thiones) with sodium nitrite in glacial AcOH led to 3,3′-bis(5,7-dialkyl-1-nitroso-6-oxo(thioxo)-1,4,4a,5,7,7a-hexahydroimidazo[4,5-e]-1,2,4-triazinyl)disulfides that decomposed spontaneously into 1,3-dialkyl-5-thioxohexahydroimidazo[4,5-d]imidazol-2(1H)-ones(thiones) in DMSO-d6 in the presence of water.

Unexpected formation of 4-alkyl-5-(4-alkylthiosemicarbazido)-4,5-dihydro-1, 2,4-triazine-3(2H)-thiones from 1,3-dialkyl-4,5-bis-(4-alkylthiosemicarbazido) imidazolidin-2-ones in acidic medium

4-Alkyl-5-(4-alkylthiosemicarbazido)-4,5-dihydro-1,2,4-triazine-3(2H) -thiones are obtained either by heating 1,3-dialkyl-4,5-bis-(4- alkylthiosemicarbazido)imidazolidin-2-ones in acidic medium or the reaction of 1,3-dialkyl-4,5-dihydroxyimidazolidin-2-on