1072004-60-4Relevant academic research and scientific papers
Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization
Shinozuka, Tsuyoshi,Tsukada, Tomoharu,Fujii, Kunihiko,Tokumaru, Eri,Shimada, Kousei,Onishi, Yoshiyuki,Matsui, Yumi,Wakimoto, Satoko,Kuroha, Masanori,Ogata, Tsuneaki,Araki, Kazushi,Ohsumi, Jun,Sawamura, Ryoko,Watanabe, Nobuaki,Yamamoto, Hideki,Fujimoto, Kazunori,Tani, Yoshiro,Mori, Makoto,Tanaka, Jun
, p. 5099 - 5117 (2018/09/17)
Attempts were made to reduce the lipophilicity of previously synthesized compound (II) for the avoidance of hepatotoxicity. The replacement of the left-hand side benzene with 2-pyridine resulted in the substantial loss of potency. Because poor membrane pe
FUSED BICYCLIC HETEROARYL DERIVATIVES
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Page/Page column 66, (2010/01/07)
Problem to be Solved The present invention relates to a novel fused bicyclic heteroaryl derivative or a pharmacologically acceptable salt thereof, which has an excellent hypoglycemic effect or treats and/or prevents the onset of a disorder of carbohydrate
