1072009-08-5

Basic information

• Product Name: 1H-Indole, 5-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
• Synonyms: 1H-Indole, 5-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;5-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indole;5-Fluoro-1H-indole-4-boronic acid, pinacol ester;5-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole, 2-(5-Fluoro-1H-indol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;5-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
• CAS NO: 1072009-08-5
• Molecular Formula: C14H17BFNO2
• Molecular Weight: 261.0996832
• Mol File: 1072009-08-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 397.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 15.99±0.30(Predicted)
• CAS DataBase Reference: 1H-Indole, 5-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 5-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-(1072009-08-5)
• EPA Substance Registry System: 1H-Indole, 5-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-(1072009-08-5)

Safety Data

• Hazardous Substances Data: 1072009-08-5(Hazardous Substances Data)

Usage

General Description

1H-Indole, 5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- is a chemical compound with a molecular formula C16H18BFNO2. It contains an indole ring with a fluorine atom and a boron-containing substituent. 1H-Indole, 5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- is commonly used in organic synthesis as a building block for the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. It is also utilized in the development of fluorescent dyes and materials for electronic applications. The boron-containing group attached to the indole ring makes this compound particularly useful in Suzuki-Miyaura coupling reactions, which are widely employed in the production of pharmaceuticals and other complex organic molecules.

Upstream product

• 955978-88-8 5-fluoro-4-iodo-1H-indole 
• 73183-34-3 bis(pinacol)diborane 
• 23077-43-2 5-fluoro-1H-indole-3-carboxylic acid 
• 310886-79-4 methyl 5-fluoro-1H-indole-3-carboxylate 
• 399-52-0 5-fluoro-1H-indole 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 

Relevant articles and documents

THIENOPYRIMIDIENE DERIVATIVES AS PI3K INHIBITORS

Thienopyrimidines of formula (I) wherein W and R1 to R4 are as defined in the claims, and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PI3 kinase, over both other class Ia and class Ib kinases. The compounds may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

2-MORPHOLIN-4-YL-PYRIMIDINES AS PI3K INHIBITORS

The invention provides compounds which are pyrimidines of formula (I) wherein R1 is a group -NR-(CHR)m-X; R2 is a substituted indolyl group; R is H or C1-C6 alkyl; m is 1, 2, 3 or 4; and X is a pyridyl ring; and the pharmaceutically acceptable salts thereof. These compounds are inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

PHARMACEUTICAL COMPOUNDS

The invention provides a compound which is a pyrimidine of formula (I): The compounds are inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.