1072121-64-2Relevant academic research and scientific papers
Design, synthesis and biological evaluation of novel stilbene-based antitumor agents
Simoni, Daniele,Invidiata, Francesco Paolo,Eleopra, Marco,Marchetti, Paolo,Rondanin, Riccardo,Baruchello, Riccardo,Grisolia, Giuseppina,Tripathi, Ashutosh,Kellogg, Glen E.,Durrant, David,Lee, Ray M.
experimental part, p. 512 - 522 (2009/08/07)
A series of novel stilbene derivatives has been synthesized and studied with the main goal to investigate SAR of the amino compound 1a, as well as to improve its water solubility, a potentially negative aspect of the molecule that could be a serious obsta
STILBENE DERIVATIVES AS NEW CANCER THERAPEUTIC AGENTS
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Page/Page column 11, (2008/12/04)
Stilbene derivatives exhibit killing and suppression of growth activity against a variety of cancer cells, and are effective at suppressing tumor growth in vivo. The stilbene derivatives may be used in the treatment of diseases characterized by cell hyperproliferation including human malignancies and non-malignant diseases such as liver cirrhosis. Stilbenes may also disrupt abnormal vessels in tumor to achieve vascular disrupting effect to suppress tumor growth. Water soluble pro-drug forms of stilbene derivatives are particularly useful in suppressing tumor growth in vivo.
