1072123-35-3Relevant academic research and scientific papers
Ru-Catalyzed dehydrogenative synthesis of antimalarial arylidene oxindoles
Bisht, Girish Singh,Pandey, Akanksha M.,Chaudhari, Moreshwar B.,Agalave, Sandip G.,Kanyal, Abhishek,Karmodiya, Krishanpal,Gnanaprakasam, Boopathy
supporting information, p. 7223 - 7229 (2018/10/23)
Ru(ii)-NHC catalyzes α-olefination of 2-oxindoles using diaryl methanols in the absence of an acceptor. A wide array of symmetrical and unsymmetrical diaryl methanols undergoes dehydrogenative coupling with 2-oxindole selectively to generate various substituted 3-(diphenylmethylene)indolin-2-one derivatives in good yields and produces environmentally benign by-products, H2 and H2O. This methodology was successfully applied for the synthesis of a bioactive drug i.e. TAS-301. The biological activities of the synthesized 3-(diphenylmethylene)indolin-2-one derivatives were screened against the Plasmodium falciparum parasite and found to exhibit a significant activity with IC50 = 2.24 μM.
Stereoselective synthesis of 3-alkylideneoxindoles by palladium-catalyzed cyclization reaction of 2-(alkynyl)aryl isocyanates with organoboron reagents
Miura, Tomoya,Toyoshima, Takeharu,Takahashi, Yusuke,Murakami, Masahiro
supporting information; experimental part, p. 4887 - 4889 (2009/05/07)
(Chemical Equation Presented) A palladium(0)/monophosphine catalyst promotes a cyclization reaction of 2-(alkynyl)aryl isocyanates with organoboron reagents to produce stereodefined 3-alkylideneoxindoles. The alkynyl and isocyanato groups undergo oxidativ
