1072157-14-2

Upstream product

• 2252-37-1 2-bromo-6-fluorobenzoic acid 
• 88-05-1 2,4,6-trimethylaniline 

Downstream Products

• 1072157-18-6 N-allyl-2-bromo-6-(2,4,6-trimethylphenylamino)benzamide 
• 1256563-42-4 C₁₇H₁₉NO₃ 
• 1256563-41-3 C₂₁H₂₇NO₂ 
• 1072157-16-4 2-acetyl-6-(2,4,6-trimethylphenylamino)benzoic acid methyl ester 
• 1085386-52-2 2-methoxy-6-(2,4,6-trimethylphenylamino)-benzamide 
• 1256563-50-4 C₁₈H₂₂N₂O₂ 
• 1085386-23-7 2-isopropoxy-6-(2,4,6-trimethylphenylamino)-benzamide 
• 1085386-62-4 2-(2-hydroxyethoxy)-6-(2,4,6-trimethyl-phenylamino)-benzamide 
• 1085386-54-4 2-(3-hydroxypropoxy)-6-(2,4,6-trimethylphenylamino)-benzamide 
• 1085386-64-6 2-(2-methoxy-ethoxy)-6-(2,4,6-trimethyl-phenylamino)-benzamide 
• 1256563-51-5 C₂₀H₂₅N₃O₂ 
• 1256563-47-9 C₁₇H₂₀N₂O 
• 1256563-48-0 C₁₉H₂₄N₂O 
• 1256563-49-1 C₂₁H₂₈N₂O 

Relevant academic research and scientific papers

Design and synthesis of selective and potent orally active S1P5 agonists

Putting the brakes on demyelination: Fingolimod (FTY720) was recently shown to significantly decrease relapse rates in patients with multiple sclerosis. This drug attenuates the trafficking of harmful T-cells entering the brain by regulating sphingosine-1-phosphate (S1P) receptors. We designed, synthesized, evaluated 2H-phthalazin-1-one derivatives (e.g., 1L) as selective S1P5 receptor agonists; these compounds are highly potent and selective, with good PK properties, and significant activity in oligodendrocytes. (Chemical Presented).

PHTHALAZINE AND ISOQUINOLINE DERIVATIVES WITH SLP RECEPTOR MODULATING ACTIVITIES

The invention relates to novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

BENZAMIDES USEFUL AS S1P RECEPTOR MODULATORS

The invention relates to novel aromatic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.