1072157-48-2Relevant academic research and scientific papers
Stereodivergent approach to both c2,8a-syn and c2,8a-anti relative stereochemical manifolds in the lepadin family via a ticl4-promoted aza-[3+3] annulation
Li, Gang,Carlson, Lauren J.,Sagamanova, Irina K.,Slafer, Brian W.,Hsung, Richard P.,Gilardi, Claudio,Sklenicka, Heather M.,Sydorenko, Nadiya
scheme or table, p. 2905 - 2914 (2010/03/30)
Details in developing a stereodivergent approach to the lepadin family and establishing an entry to both C2,8a-syn and C2,8a-anti relative stereochemical manifolds through a common intermediate are described here. This works paves the foundation for const
Total synthesis of (+)-lepadin F
Li, Gang,Hsung, Richard P.,Slafer, Brian W.,Sagamanova, Irina K.
supporting information; experimental part, p. 4991 - 4994 (2009/05/31)
(Chemical Equation Presented) An enantioseleclive total synthesis of (+)-lepadin F is described. The synthetic sequence features an intermolecular aza-[3 + 3] annulation, homologation of a vinylogous amide via Eschenmoser's episulfide contraction, and a highly stereoselective hydrogenation essential for achieving the 1,3-anti relative stereochemistry at C2 and C8a.
