1072450-36-2

Upstream product

• 1026022-15-0 O-triisopropylsilyl [2,4-di-O-benzyl-β-D-xylopyranosyl-(1->4)]-2,3-di-O-isopropylidene-α-L-rhamnopyranoside 
• 242143-00-6 methyl 2,3,4-tri-O-benzyl-D-xylopyranoside 
• 91-09-8 methyl xyloside 
• 87-72-9 D-Xylose 
• 100639-25-6 allyl 2,3-O-isopropylidene-α-L-rhamnopyranoside 
• 83441-63-8 1-O-(trichloroacetimidoyl)-2,3,4-tri-O-benzyl-α-D-xylopyranose 
• 18039-26-4 2,3,4-tri-O-benzyl-D-xylopyranose 
• 100-44-7 benzyl chloride 
• 850004-55-6 (3R,4S,5R)-2-Allyloxy-3,5-bis-benzyloxy-tetrahydro-pyran-4-ol 
• 182212-10-8 1-O-allyl-D-xylopyranoside 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 1026022-06-9 O-triisopropylsilyl 2,3-di-O-isopropylidene-α-L-rhamnopyranoside 
• 1026022-05-8 O-triisopropylsilyl 4-O-benzyl-2,3-di-O-isopropylidene-α-L-rhamnopyranoside 
• 89821-77-2 Allyl 4-O-benzyl-2,3-O-isopropylidene-α-L-rhamnopyranoside 

Relevant academic research and scientific papers

TRITERPENE SAPONIN SYNTHESIS, INTERMEDIATES AND ADJUVANT COMBINATIONS

The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.

Synthesis of QS-21-xylose: Establishment of the immunopotentiating activity of synthetic QS-21 adjuvant with a melanoma vaccine

(Chemical Equation Presented) A helping hand: The adjuvant QS-21-xylose (see structure; the xylose residue is shown in red) was obtained in pure form by chemical synthesis. When combined with its synthetic apiose isomer to furnish synthetic QS-21 (sQS-21), the saponin combination was shown to aid the production of antibodies in mice when injected with a melanoma vaccine. The preparation of sQS-21 provides access to pure, functional saponin adjuvants of defined composition.