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107266-08-0

Carvotroline is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 8-fluoro-2-(2-pyridin-4-ylethyl)-1,3,4,5-tetrahydropyrido[4,3-b]indole

    Cas No: 107266-08-0

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  • 107266-08-0 Structure

  • Basic information

    1. Product Name: Carvotroline
    2. Synonyms: Carvotroline
    3. CAS NO:107266-08-0
    4. Molecular Formula: C18H18FN3
    5. Molecular Weight: 295.359
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 107266-08-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 472.5°Cat760mmHg
    3. Flash Point: 239.6°C
    4. Appearance: /
    5. Density: 1.254g/cm3
    6. Vapor Pressure: 4.25E-09mmHg at 25°C
    7. Refractive Index: 1.652
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: Carvotroline(CAS DataBase Reference)
    11. NIST Chemistry Reference: Carvotroline(107266-08-0)
    12. EPA Substance Registry System: Carvotroline(107266-08-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 107266-08-0(Hazardous Substances Data)

107266-08-0 Usage

Uses

Antipsychotic.

Check Digit Verification of cas no

The CAS Registry Mumber 107266-08-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,2,6 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 107266-08:
(8*1)+(7*0)+(6*7)+(5*2)+(4*6)+(3*6)+(2*0)+(1*8)=110
110 % 10 = 0
So 107266-08-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H18FN3/c19-14-1-2-17-15(11-14)16-12-22(10-6-18(16)21-17)9-5-13-3-7-20-8-4-13/h1-4,7-8,11,21H,5-6,9-10,12H2

107266-08-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-fluoro-2-(2-pyridin-4-ylethyl)-1,3,4,5-tetrahydropyrido[4,3-b]indole

1.2 Other means of identification

Product number -
Other names Carvotroline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:107266-08-0 SDS

107266-08-0Downstream Products

107266-08-0Relevant articles and documents

Antipsychotic γ-carbolines

-

, (2008/06/13)

The compounds: STR1 in which R1 is hydrogen, halogen, hydroxy, or alkyl; R2 is substituted or unsubstituted pyridinyl, pyrazinyl, quinolinyl or quinoxalinyl and said substituents are alkyl, alkoxy, alkoxycarbonyl, halogen, cyano or nitro; and n is 2, 3, 4, 5 or 6; or a pharmaceutically acceptable salt thereof, are antipsychotic and anxiolytic agents.

Antipsychotic Activity of Substituted γ-Carbolines

Abou-Gharbia, Magid,Patel, Usha R.,Webb, Michael B.,Moyer, John A.,Andree, Terrance H.,Muth, Eric A.

, p. 1818 - 1823 (2007/10/02)

Several novel substituted γ-carbolines were synthesized and examined in a series of in vitro and in vivo pharmacological tests to determine potential antipsychotic activity.Most compounds were orally active in blocking the conditioned avoidance response (CAR) in rats but did not antagonize apomorphine-induced stereotyped behavior.Compound 17 (Wy-47,384), a γ-carboline with a 3-(3-pyridinyl)propyl side chain, was selected for development as an atypical antipsychotic agent because of its potent and selective profile in preclinical psychopharmacological tests.It blocked CAR in rats with an AB50 of 14 mg/kg po, showed weak affinity for the D2 receptor site (Ki = 104 nM), and showed differential potency in antagonizing apomorphine-induced stereotyped behavior (ED50 = 11 mg/kg ip) and climbing behavior (ED50 = 4 mg/kg ip).Such activities are suggestive of antipsychotic efficacy combined with a low potential for extrapyramidal side effect (EPS) liability.

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