1072833-90-9

Upstream product

• 1310383-72-2 (aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate 
• 1072833-89-6 [(2,3-difluorobenzoyl)amino]acetic acid 
• 1072833-88-5 methyl [(2,3-difluorobenzoyl)amino]acetate 
• 4519-39-5 2,3-difluorobenzoic acid 

Downstream Products

• 1072833-64-7 [(1R)-1-({[(2,3-difluorobenzoyl)amino]acetyl}amino)-3-methylbutyl]boronic acid 

Relevant academic research and scientific papers

PROTEASOME INHIBITOR

PROBLEM TO BE SOLVED: To provide a novel compound useful as a proteasome inhibitor. SOLUTION: The invention also provides a pharmaceutical composition comprising the compound, and a method of using the composition for treatment of various diseases. The compound is a compound of the general formula (I) or a pharmaceutical acceptable salt or boronic acid anhydride thereof. In the formula, Z1 and Z2 are each independently hydroxy, alkoxy, aryloxy or aralkoxy, or Z1 and Z2 together form a moiety derived from a boronic acid complexing agent. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Proteasome inhibitor

PROBLEM TO BE SOLVED: To provide a new compound useful as a proteasome inhibitor which is a multicatalytic protease, and a pharmaceutical composition containing the compound. SOLUTION: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or boronic anhydride thereof, and a pharmaceutical composition containing them. (A is a halogen atom-substituted phenyl group; and Z1 and Z2 are each independently hydroxy, alkoxy, aryloxy or aralkoxy, where Z1 and Z2 may be both a moiety derived from a boronic acid complexing agent.) COPYRIGHT: (C)2016,JPOandINPIT

PROTEASOME INHIBITORS

The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

Proteasome inhibitor composition and use thereof (by machine translation)

This application relates to proteasome inhibitor and its composition and use. The present invention provides a novel compound of a proteasome inhibitor. The invention also provides containing the compounds of the invention, a pharmaceutical composition of composition and the method for the treatment of various diseases. (by machine translation)

PROTEASOME INHIBITORS

The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

Proteasome inhibitors

The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.