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1072845-47-6

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1072845-47-6 Usage

General Description

FMoc-α-Me-Asp(OtBu)-OH is a chemical compound used in peptide synthesis as a building block for the formation of peptides. It is a derivative of α-Methylaspartic acid, with an Fmoc (9-fluorenylmethyloxycarbonyl) protecting group attached to the α-amino group and a tert-butoxycarbonyl (Boc) protecting group attached to the carboxylic acid group. FMoc-α-Me-Asp(OtBu)-OH is commonly used in solid-phase peptide synthesis due to its ability to protect the α-amino and carboxylic acid groups, while also being easily cleaved under mild conditions to reveal the free α-Me-Asp(OtBu)-OH for further peptide elongation. FMoc-α-Me-Asp(OtBu)-OH plays a crucial role in the creation of specific peptide sequences, making it an important tool in the field of peptide chemistry and drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 1072845-47-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,2,8,4 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1072845-47:
(9*1)+(8*0)+(7*7)+(6*2)+(5*8)+(4*4)+(3*5)+(2*4)+(1*7)=156
156 % 10 = 6
So 1072845-47-6 is a valid CAS Registry Number.

1072845-47-6Downstream Products

1072845-47-6Relevant articles and documents

Synthesis and stability evaluation of novel peptidomimetic Caspase-1 inhibitors for topical application

Chambon, Sandrine,Talano, Sandrine,Millois, Corinne,Dumais, Laurence,Pierre, Romain,Tomas, Loic,Mathieu, Céline,Ghilini, Anne-Laurence,Vanthuyne, Nicolas,Reverse, Kevin,Brethon, Anne,Rodeschini, Vincent,Comino, Catherine,Mouis, Grégoire,El-Bazbouz, Ghizlane,Clary, Laurence,Fournier, Jean-Fran?ois,Bouix-Peter, Claire,Harris, Craig S.,Hennequin, Laurent F.

, p. 4805 - 4822 (2018)

During our search for topically-active Caspase-1 inhibitors, we identified a novel class of potent inhibitors based on a 1,3,5-trisubstituted uracil motif equipped with an L-aspartate semi-aldehyde derived warhead. In the literature, the majority of Caspase-1 inhibitors possessing the same warhead have been designed and evaluated for oral administration as the ethyl acetal pro-drug form. For our topical program, the pro-drug acetal form was not fully hydrolysed in the skin and was unstable in many of our standard topical excipients, therefore, we were obliged to focus on the actual hemiacetal drug form of the molecule during our drug discovery program. Our work focuses on both the synthesis and achiral and chiral stability of the final drug molecules in topical excipients.

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