1072880-82-0

Basic information

• Product Name: 4-(3-Methoxyphenyl)oxazole
• Synonyms: 4-(3-Methoxyphenyl)oxazole
• CAS NO: 1072880-82-0
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18396
• Mol File: 1072880-82-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(3-Methoxyphenyl)oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Methoxyphenyl)oxazole(1072880-82-0)
• EPA Substance Registry System: 4-(3-Methoxyphenyl)oxazole(1072880-82-0)

Safety Data

• Hazardous Substances Data: 1072880-82-0(Hazardous Substances Data)

Usage

General Description

4-(3-Methoxyphenyl)oxazole is a chemical compound with the molecular formula C11H9NO2. It is an oxazole derivative, which is a type of heterocyclic compound containing a five-membered ring with three carbon atoms, one nitrogen atom, and one oxygen atom. The presence of a methoxy group at the third position of the phenyl ring in the molecule gives it its specific name. 4-(3-Methoxyphenyl)oxazole has been studied for its potential biological activities, including antimicrobial and antifungal properties. It is also used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Additionally, 4-(3-Methoxyphenyl)oxazole has been investigated for its potential use in organic electronic devices due to its interesting electronic and optical properties.

Upstream product

• 77287-34-4 formamide 
• 5000-65-7 2-bromo-3'-methoxyacetophenone 

Downstream Products

• 1072880-83-1 4-(3-hydroxy-phenyl)-oxazole 
• 1092465-16-1 2-chloro-4-(3-methoxy-phenyl)-oxazole 

Relevant articles and documents

3-Heterocycle-phenyl N-alkylcarbamates as FAAH inhibitors: Design, synthesis and 3D-QSAR studies

Carbamates are a well-established class of fatty acid amide hydrolase (FAAH) inhibitors. Here we describe the synthesis of meta-substituted phenolic N-alkyl/aryl carbamates and their in vitro FAAH inhibitory activities. The most potent compound, 3-(oxazol-2yl)phenyl cyclohexylcarbamate (2a), inhibited FAAH with a sub-nanomolar IC50 value (IC50=0.74 nM). Additionally, we developed and validated three-dimensional quantitative structure-activity relationships (QSAR) models of FAAH inhibition combining the newly disclosed carbamates with our previously published inhibitors to give a total set of 99 compounds. Prior to 3D-QSAR modeling, the degree of correlation between FAAH inhibition and in silico reactivity was also established. Both 3D-QSAR methods used, CoMSIA and GRID/GOLPE, produced statistically significant models with coefficient of correlation for external prediction (R2 PRED) values of 0.732 and 0.760, respectively. These models could be of high value in further FAAH inhibitor design.

HETEROCYCLIC PHENYL CARBAMATES AS NOVEL FAAH-INHIBITORS

Fatty acid amide hydrolase inhibitors of the Formula (I) are provided, wherein R is a heterocyclic or heterocyclic carbonyl moiety and R' is a group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted