1072916-81-4

Basic information

• Product Name: (S)-N-(3-oxo-1-phenylpropyl)benzamide
• Synonyms: (S)-N-(3-oxo-1-phenylpropyl)benzamide
• CAS NO: 1072916-81-4
• Molecular Weight: 253.301
• Mol File: 1072916-81-4.mol

Chemical Properties

• CAS DataBase Reference: (S)-N-(3-oxo-1-phenylpropyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(3-oxo-1-phenylpropyl)benzamide(1072916-81-4)
• EPA Substance Registry System: (S)-N-(3-oxo-1-phenylpropyl)benzamide(1072916-81-4)

Safety Data

• Hazardous Substances Data: 1072916-81-4(Hazardous Substances Data)

Upstream product

• 10374-29-5 N-benzylidenebenzamide 
• 75-07-0 acetaldehyde 
• 201230-82-2 carbon monoxide 
• 155242-42-5 2,4-diphenyl-Δ²-oxazoline 

Downstream Products

• 1072916-80-3 (S)-3-benzoylamino-3-phenylpropanol 

Relevant articles and documents

Stereoselective organocatalytic one-pot α,α-bifunctionalization of acetaldehyde by a tandem mannich reaction/electrophilic amination

The first asymmetric organocatalyzed one-pot α,α- bifunctionalization of acetaldehyde with two different electrophiles is described. A diarylprolinol silyl ether-catalyzed reaction of acetaldehyde with an imine and di-tert-butyl azodicarboxylate affords s

Asymmetric synthesis of maraviroc (UK-427,857)

The asymmetric synthesis of Maraviroc (UK-427,857), a chemochine receptor 5 (CCR-5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral βamino aldehyde key fragment is presented. The reactions were performed on a gram-scale and allow for the rapid construction of new Maraviroc analogues.

β-Amidoaldehydes via oxazoline hydroformylation

4-Substituted oxazolines, which are readily synthesized from naturally occurring α-amino acids, are converted efficiently and stereospecifically to β-amidoaldehydes in the presence of synthesis gas and catalytic dicobalt octacarbonyl.

Direct organocatalytic Mannich reaction of acetaldehyde: An improved catalyst and mechanistic insight from a computational study

(Chemical Equation Presented) A chiral diaryl prolinol silyl ether organocatalyst with an acidis used for the direct catalytic asymmetric Mannich reaction of acetaldehyde and imines. N-Benzoyl-, N-tert-butoxycarbonyl-, and N-toluene-4-sulfonylimines can be employed to produce synthetically useful β-amino aldehydes in goodyield s andwith excellent enantioselectivity (see scheme). The reaction mechanism was investigated quantum-mechanically.