1072921-02-8Relevant articles and documents
Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists
Brown, Brian S.,Keddy, Ryan,Zheng, Guo Zhu,Schmidt, Robert G.,Koenig, John R.,McDonald, Heath A.,Bianchi, Bruce R.,Honore, Prisca,Jarvis, Michael F.,Surowy, Carol S.,Polakowski, James S.,Marsh, Kennan C.,Faltynek, Connie R.,Lee, Chih-Hung
, p. 8516 - 8525 (2008/12/23)
A series of 1,2,3,6-tetrahydropyridyl-4-carboxamides, exemplified by 6, have been synthesized and evaluated for in vitro TRPV1 antagonist activity, and in vivo analgesic activity in animal pain models. The tetrahydropyridine 6 is a novel TRPV1 receptor an