1072936-41-4Relevant academic research and scientific papers
Highly enantioselective [3+2] cycloadditions of terminal allenoates with β-trifluoromethyl α,β-enones
Li, Maizhan,Zhou, Wei
, p. 8842 - 8845 (2020)
Highly enantio- and diastereoselective phosphine-catalyzed [3+2] cycloadditions of terminal allenoates with β-perfluoroalkyl α,β-enones leading to a range of trifluoromethylated cyclopentenes with two contiguous chiral centers (up to 99percent yield with 99percent ee) have been developed. Moreover, these reactions could be performed at the gram scale by using only 1 molpercent catalyst. The method developed here was also applied to the concise synthesis of trifluoromethylated DGAT-1 inhibitor. This journal is
