1072937-61-1

Basic information

• Product Name: 5-formyl-2-hydroxybiphenyl-3-carboxylic acid methyl ester
• Synonyms: 5-formyl-2-hydroxybiphenyl-3-carboxylic acid methyl ester
• CAS NO: 1072937-61-1
• Molecular Weight: 256.258
• Mol File: 1072937-61-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-formyl-2-hydroxybiphenyl-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-formyl-2-hydroxybiphenyl-3-carboxylic acid methyl ester(1072937-61-1)
• EPA Substance Registry System: 5-formyl-2-hydroxybiphenyl-3-carboxylic acid methyl ester(1072937-61-1)

Safety Data

• Hazardous Substances Data: 1072937-61-1(Hazardous Substances Data)

Upstream product

• 861514-69-4 methyl 3-bromo-5-formyl-2-hydroxybenzoate 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1072937-64-4 methyl 5-[(E)-2-phenylvinyl]-2-hydroxybiphenyl-3-carboxylate 

Relevant articles and documents

Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity

Disalicylic acid derivatives with stilbene and bis-styrylbenzene skeleton were synthesized as PTP1B inhibitors. The most potent in this series exhibited a submicromolar IC50 value. One of the compounds 7b was tested in an animal model for its efficacy as an anti-diabetic or an anti-obesity agent. In feeding compound 7b to diet-induced obese mice, no significant differences in weight gain and food consumption were observed between the drug-treated and the obese control mice. However, 7b significantly lowered the fasting glucose level and improved the glucose tolerance in the obesity-induced diabetic mice.