1072943-99-7

Basic information

• Product Name: 4-(2-hydroxybenzoyl)-2-(pyridyl-2-yl)-1H-pyrazol-3-ol
• CAS NO: 1072943-99-7
• Molecular Weight: 295.298
• Mol File: 1072943-99-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-hydroxybenzoyl)-2-(pyridyl-2-yl)-1H-pyrazol-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-hydroxybenzoyl)-2-(pyridyl-2-yl)-1H-pyrazol-3-ol(1072943-99-7)
• EPA Substance Registry System: 4-(2-hydroxybenzoyl)-2-(pyridyl-2-yl)-1H-pyrazol-3-ol(1072943-99-7)

Safety Data

• Hazardous Substances Data: 1072943-99-7(Hazardous Substances Data)

Upstream product

• 4930-98-7 pyrid-2-ylhydrazine 
• 2555-37-5 3-acetyl-4-hydroxychromen-2-one 

Downstream Products

• 1072944-00-3 [dichloro(4-(2-hydroxybenzoyl)-2-(pyridyl-2-yl)-1H-pyrazol-3-ol)platinum] 

Relevant articles and documents

Synthesis, structure, protolytic properties, alkylating and cytotoxic activity of novel platinum(II) and palladium(II) complexes with pyrazole-derived ligands

Novel platinum(II) and palladium(II) complexes [PtCl2(HL 1)] (3a), [NH2CH3)2][PtCl 2(L1)] (3b), [PdCl2(HL1)] (4a), [NH2(CH3)2][PdCl2(L1)] (4b) and [PdCl(CH3CN)(L1)] (4c), where HL1 = 4-(2-hydroxybenzoyl)-2-(pyridin-2-yl)-1H-pyrazol-3-ol, have been synthesised as potential anticancer compounds. Protonation constants of the ligand were determined by pH-metric titration (log K1 = 7.74 ± 0.03; log K2 = 2.85 ± 0.05). The solid-state structures of complexes 3b and 4c have been determined by X-ray diffraction, showing sguare-planar coordination geometry of PtII and PdII ions. In addition, the compounds have been characterised by IR, 1H NMR and FAB mass spectrometry. The results of preliminary studies on the cytotoxic activity in vitro against HL-60 and NALM-6 leukaemia cell lines are also reported and the IC50 values compared with those of the metal-free ligand and cisplatin. Cytotoxic evaluation revealed that PtII and Pd II complexes were active in the micromolar concentration range. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.