1072944-89-8

Basic information

• Product Name: 5-AMINO-1-(3-BROMOPHENYL)-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE
• Synonyms: 5-AMINO-1-(3-BROMOPHENYL)-4-CYANO-3-METHYLPYRAZOLE;5-AMINO-1-(3-BROMOPHENYL)-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE
• CAS NO: 1072944-89-8
• Molecular Formula: C₁₁H₉BrN₄
• Molecular Weight: 277.11996
• Mol File: 1072944-89-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 459.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.59±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.69±0.13(Predicted)
• CAS DataBase Reference: 5-AMINO-1-(3-BROMOPHENYL)-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-(3-BROMOPHENYL)-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE(1072944-89-8)
• EPA Substance Registry System: 5-AMINO-1-(3-BROMOPHENYL)-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE(1072944-89-8)

Safety Data

• Hazardous Substances Data: 1072944-89-8(Hazardous Substances Data)

Usage

Uses

5-Amino-1-(3-bromophenyl)-4-cyano-3-methylpyrazole is used as a reactant in the preparation of phenylpyrazole derivatives as novel anti-HIV agents. Also used in the synthesis of tetrazole compounds against Leishmania.

Upstream product

• 27246-81-7 3-bromophenylhydrazine hydrochloride 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 40887-80-7 3-bromophenylhydrazine 

Downstream Products

• 1448812-40-5 N-(5-(((1-(3-bromophenyl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-3-chloro-2-hydroxyphenyl)propionamide 
• 1448812-69-8 1-([1,1'-biphenyl]-3-yl)-5-amino-3-methyl-1H-pyrazole-4-carbonitrile 

Relevant articles and documents

The pyrazole derivative or its salt in a pharmaceutical composition containing them

PROBLEM TO BE SOLVED: To provide a novel compound and a pharmaceutical composition useful for treatment and/or prevention of HIV virus infections.SOLUTION: Provided is a pyrazole derivative represented by the general formula (I) or a salt thereof (in the

Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents

The structure-activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of benzaldehydes with 5-aminopyrazoles and carried out parallel structural optimization on the benzyl group and the pyrazole ring. This optimization led to a six-fold more potent derivative 32j than the lead compound 1, and this derivative has a 3′,4′-dichloro-(1,1′-biphenyl)-3-yl group.