1072952-45-4 Usage
Uses
Used in Organic Synthesis:
2-Fluoro-5-methylpyridine-3-boronic acid is used as a versatile building block in organic synthesis for the construction of various biologically active molecules. Its boronic acid group allows it to participate in Suzuki-Miyaura cross-coupling reactions, which are widely used for the formation of C-C bonds, enabling the creation of complex organic compounds with potential applications in various fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-Fluoro-5-methylpyridine-3-boronic acid is used as a key intermediate in the development of new drugs and pharmaceutical agents. The presence of the fluoro-methyl substituent can impart unique properties to the resulting molecules, such as enhanced lipophilicity, metabolic stability, or binding affinity, which are crucial for the design of effective and selective drug candidates.
Used in Drug Development:
2-Fluoro-5-methylpyridine-3-boronic acid is utilized in drug development as a starting material or intermediate for the synthesis of potential drug candidates. Its reactivity in cross-coupling reactions allows for the rapid assembly of diverse molecular frameworks, facilitating the exploration of structure-activity relationships and the optimization of drug candidates with improved potency, selectivity, and pharmacokinetic properties.
Overall, 2-Fluoro-5-methylpyridine-3-boronic acid is an important chemical for the advancement of organic chemistry and pharmaceutical sciences, playing a crucial role in the discovery and development of novel biologically active compounds and therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1072952-45-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,2,9,5 and 2 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1072952-45:
(9*1)+(8*0)+(7*7)+(6*2)+(5*9)+(4*5)+(3*2)+(2*4)+(1*5)=154
154 % 10 = 4
So 1072952-45-4 is a valid CAS Registry Number.
1072952-45-4Relevant academic research and scientific papers
Structure-based design of a novel series of potent, selective inhibitors of the class i phosphatidylinositol 3-kinases
Smith, Adrian L.,D'Angelo, Noel D.,Bo, Yunxin Y.,Booker, Shon K.,Cee, Victor J.,Herberich, Brad,Hong, Fang-Tsao,Jackson, Claire L. M.,Lanman, Brian A.,Liu, Longbin,Nishimura, Nobuko,Pettus, Liping H.,Reed, Anthony B.,Tadesse, Seifu,Tamayo, Nuria A.,Wurz, Ryan P.,Yang, Kevin,Andrews, Kristin L.,Whittington, Douglas A.,McCarter, John D.,Miguel, Tisha San,Zalameda, Leeanne,Jiang, Jian,Subramanian, Raju,Mullady, Erin L.,Caenepeel, Sean,Freeman, Daniel J.,Wang, Ling,Zhang, Nancy,Wu, Tian,Hughes, Paul E.,Norman, Mark H.
experimental part, p. 5188 - 5219 (2012/08/28)
A highly selective series of inhibitors of the class I phosphatidylinositol 3-kinases (PI3Ks) has been designed and synthesized. Starting from the dual PI3K/mTOR inhibitor 5, a structure-based approach was used to improve potency and selectivity, resulting in the identification of 54 as a potent inhibitor of the class I PI3Ks with excellent selectivity over mTOR, related phosphatidylinositol kinases, and a broad panel of protein kinases. Compound 54 demonstrated a robust PD-PK relationship inhibiting the PI3K/Akt pathway in vivo in a mouse model, and it potently inhibited tumor growth in a U-87 MG xenograft model with an activated PI3K/Akt pathway.
