107299-23-0

Upstream product

• 17920-90-0 3,3,7-trimethyl-oct-6-enal 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 5392-40-5 (E/Z)-3,7-dimethyl-2,6-octadienal 

Downstream Products

• 107259-70-1 (1S,2R)-trans-2-isopropyl-5,5-dimethylcyclohexanol 
• 107299-25-2 (1S,2R)-2-Isopropyl-5,5-dimethyl-cyclohexylamine 
• 107259-70-1 (-)-cis-(1R,2R)-2-isopropyl-5,5-dimethylcyclohexanol 
• 77495-29-5 ((1S,2R)-2-Isopropenyl-5,5-dimethyl-cyclohexyl)-((R)-1-phenyl-ethyl)-amine 

Relevant academic research and scientific papers

ASYMMETRIC CYCLIZATION OF UNSATURATED ALDEHYDES CATALYZED BY A CHIRAL LEWIS ACID

A highly enantioselective cyclization of unsaturated aldehydes has been accomplished with the chiral zinc reagent 1 derived from dimethylzinc and (R)-(+)-1,1'-bi-2-naphthol.Thus, the Aldehyde 2 and 10 are treated with the reagent 1 producing the trans alcohol 3 and 11, respectively, with high optical purity (>90percent ee).In sharp contrast, the aldehyde 8 affords the totally racemic alcohol 9.Since the chiral zinc reagent 1 possesses its C2-symmetry, either enantiomer can be prepared from the unsaturated aldehyde by choosing the chiral ligand, (R)-(+)- or (S)-(-)-1,1'-bi-2-naphthol.