1073106-05-4

Basic information

• Product Name: (S)-1-(2',4'-dichlorophenyl)propan-1-ol
• Synonyms: (S)-1-(2',4'-dichlorophenyl)propan-1-ol;(S)-1-(2,4-dichlorophenyl)propanol
• CAS NO: 1073106-05-4
• Molecular Weight: 205.084
• Mol File: 1073106-05-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (S)-1-(2',4'-dichlorophenyl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(2',4'-dichlorophenyl)propan-1-ol(1073106-05-4)
• EPA Substance Registry System: (S)-1-(2',4'-dichlorophenyl)propan-1-ol(1073106-05-4)

Safety Data

• Hazardous Substances Data: 1073106-05-4(Hazardous Substances Data)

Upstream product

• 37885-41-9 2',4'-dichloropropiophenone 
• 557-20-0 diethylzinc 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 541-73-1 1,3-Dichlorobenzene 

Relevant articles and documents

Vasicine as tridentate ligand for enantioselective addition of diethylzinc to aldehydes

The first report of natural l-vasicine as tridentate chiral ligand for the enantioselective addition of diethylzinc to a variety of aliphatic and aromatic aldehydes is described. The ligand generates R-isomer of the secondary alcohols upto 98% ee. The qui

Candida tenuis xylose reductase catalyzed reduction of aryl ketones for enantioselective synthesis of active oxetine derivatives

Candida tenuis xylose reductase shows high catalytic efficiencies in carbonyl reduction of acetophenone and 1-phenyl-1-propanone derivatives. The quite low substrate solubility in aqueous buffer systems is circumvented by addition of methanol or by two-phase solvent systems. In the latter, methanol improves the substrate phase transfer as solvent mediator and leads to reasonable space/time yields. Resulting enantiomerically pure chiral alcohols are key intermediates for synthesis of active pharmaceutical ingredients. (R)-Atomoxetine is exemplarily synthesized in four steps, and the further use for generation of other oxetine derivatives and a polo-like kinase 1 inhibitor are discussed. Copyright

A systematic study of chiral homoprolinols and their derivatives in the catalysis of enantioselective addition of diethylzinc to aldehydes

Homoprolinol analogs, a class of optically active γ-amino alcohols, were examined systematically in the enantioselective addition reactions of diethylzinc to aldehydes. By comparison of the results catalyzed by these γ-amino alcohols with those by the β-amino alcohols based on pyrrolidine architecture reported in the literature references, we have observed that the γ-amino alcohols are superior to the corresponding β-amino alcohols when the nitrogen and the oxygen are unsubstituted. Among the homoprolinols we tested, 2b gave the best results (45-88% yields, 44-81% ee) in the addition reactions. To the best of our knowledge, 2b has been noticed as one of the most efficient γ-amino alcohol catalysts based on pyrrolidine framework.