107311-60-4Relevant academic research and scientific papers
Antirhinoviral Activity of Heterocyclic Analogs of Win 54954
Bailey, Thomas R.,Diana, Guy D.,Kowalczyk, Paul J.,Akullian, Vahan,Eissenstat, Michael A.,et al.
, p. 4628 - 4633 (2007/10/02)
A variety of heterocyclic analogs of Win 54954 have been synthesized and tested in vitro against human rhinovirus type 14 (HRV-14) in a plaque reduction assay.The more active compounds were tested against 14 additional serotypes, and the concentration whi
A model for compounds active against human rhinovirus-14 based on X-ray crystallography data
Diana,Treasurywala,Bailey,Oglesby,Pevear,Dutko
, p. 1306 - 1311 (2007/10/02)
A number of (oxazolinylphenyl)isoxazoles have been synthesized and tested against human rhinovirus-14 (HRV-14). Several of the more active compounds have been examined by X-ray crystallography and their orientation in the compound binding site on the caps
Heterocyclic substituted-phenoxyalkylisoxazoles as antiviral useful agents
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, (2008/06/13)
Compounds of the formula STR1 wherein: Y is an alkylene bridge of 3-9 carbon atoms; Z is N or HC; R is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when Z is N, R is lower-alkyl; R1 and R2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; and Het is selected from specified heterocyclic groups, are useful and antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.
