1073159-68-8Relevant academic research and scientific papers
Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs
Gao, Hongying,Wu, Yue,Sun, Yonghui,Yang, Yiqing,Zhou, Guangbiao,Rao, Yu
, p. 1855 - 1862 (2020)
Focal adhesion kinase (FAK), a cytoplasmic protein tyrosine kinase, exerts kinase-dependent enzymatic functions and kinase-independent scaffolding functions, both of which are crucial in cancer development, early embryonic development, and reproduction. H
SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
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Page/Page column 36, (2009/04/24)
The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
