107319-99-3Relevant academic research and scientific papers
TOTAL SYNTHESIS OF OPTICALLY ACTIVE INTEGERRIMINE, A TWELVE-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID OF RETRONECINE TYPE. I. ENANTIOSELECTIVE SYNTHESIS OF THE PROTECTED (+)-INTEGERRINECIC ACID
Niwa, Haruki,Miyachi, Yasuyoshi,Uosaki, Youichi,Yamada, Kiyoyuki
, p. 4601 - 4604 (1986)
For the total synthesis of optically active integerrimine, the twelve-membered dilactonic pyrrolizidine alkaloid, the necic acid component (+)-integerrinenic acid has been enantioselectively synthesized in the protected form.
Total Synthesis of Optically Active Integerrimine, a Twelve-membered Dilactonic Pyrrolizidine Alkaloid of Retronecine Type
Niwa, Haruki,Miyachi, Yasuyoshi,Okamoto, Osamu,Uosaki, Youichi,Kuroda, Akio,et al.
, p. 393 - 412 (2007/10/02)
A total synthesis of the natural enantiomer of integerrimine (1), a twelve-membered dilactonic pyrrolizidine alkaloid of retronecine type has been achieved through the enantioselective synthesis and regioselective coupling of (+)-retronecine (4) and (+)-integerrinecic acid (methylthio)methyl ether (6).
