1073193-41-5Relevant academic research and scientific papers
Efficient synthesis of racemic β-aminophosphonates via aza-Michael reaction in water
Matveeva, Ekaterina V.,Petrovskii, Pavel V.,Odinets, Irina L.
, p. 6129 - 6133 (2008)
Water as a solvent significantly accelerates the addition of various amines to diethyl vinylphosphonate to yield β-aminophosphonates without any catalyst compared to known procedures for such aza-Michael reactions. The products are obtained in quantitative yields and high purity over short reaction times. Using a reactant ratio (vinylphosphonate/amine) of 2:1 resulted in double phosphorylation of primary amines.
