107324-93-6Relevant articles and documents
FGFR INHIBITOR AND APPLICATION THEREOF
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Paragraph 0276; 0278, (2020/01/22)
An azatricyclic compound (as represented by formula I) which acts as an inhibitor of fibroblast growth factor receptors (FGFR), as well as a pharmaceutical composition thereof, a preparation method, and a use therefor in the treatment of FGFR-mediated diseases. The azatricyclic compound exerts an effect by means of participating in the regulation of a plurality of processes such as cell proliferation, apoptosis, migration, neovascularization, and the like. AA%%%Formula (I).
PROCESSES FOR PREPARING PEPTIDE CONJUGATES AND LINKERS
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Paragraph 0173-0177, (2015/02/19)
The present invention provides a process for preparing a compound of Formula 5b, as well as intermediates thereof, and novel classes of compounds useful in process for preparing these and similar compounds.
Chromatography- and lyophilization-free synthesis of a peptide- linker conjugate
Magano, Javier,Bock, Brandon,Brennan, John,Farrand, Douglas,Lovdahl, Michael,Maloney, Mark T.,Nadkarni, Durgesh,Oliver, Wendy K.,Pozzo, Mark J.,Teixeira, John J.,Wang, Jian,Rizzo, John,Tumelty, David
, p. 142 - 151 (2014/05/20)
An optimized and scalable process to manufacture peptide-linker conjugate 1 is reported that avoids the chromatographic purification and lyophilization that are typically required for the isolation of this type of compound. An operationally simple protoco
