1073339-07-7

Usage

Uses

Used in Organic Synthesis:
2-(2,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is used as a boronic ester in organic synthesis for its steric hindrance and reactivity in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of carbon-carbon bonds.
Used in Drug Discovery:
In the pharmaceutical industry, 2-(2,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is used as a building block for the development of new drugs, leveraging its unique structural properties to create novel molecular entities with potential therapeutic applications.
Used in Material Science:
2-(2,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is also utilized as a component in material science, where its incorporation into new materials can lead to advancements in material properties and functionalities.

Upstream product

• 2100-42-7 2-chloro-1,4-dimethoxybenzene 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 150-78-7 1,4-dimethoxybezene 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 73183-34-3 bis(pinacol)diborane 

Relevant academic research and scientific papers

Ortho-Selective C-H Borylation of Aromatic Ethers with Pinacol-borane by Organo Rare-Earth Catalysts

The regioselective C-H borylation of aromatic ethers such as anisoles is of much interest and importance, but has remained a challenge to date. We report herein the catalytic ortho-selective C-H borylation of a wide range of aromatic ethers with pinacolborane (HBpin) by rare-earth metallocene complexes. This protocol offers an efficient and straightforward route for the synthesis of a variety of borylated aromatic ether derivatives. A proper metal/ligand combination for the rare-earth metal catalysts was found to be critically important to promote this transformation.

Method for preparing aminoarylborane compounds or derivatives thereof

The present invention provides a process for the preparation of aminoarylborane compounds and derivatives thereof comprising a step of arylation by reacting an aryl chloride with an aminoborane compound in the presence of a catalytic system. Typically, th

METHOD FOR PREPARING AMINOARYLBORANE COMPOUNDS OR DERIVATIVES THEREOF

The present invention provides a process for the preparation of aminoarylborane compounds and derivatives thereof comprising a step of arylation by reacting an aryl chloride with an aminoborane compound in the presence of a catalytic system.

Borylation of unactivated aryl chlorides under mild conditions by using diisopropylaminoborane as a borylating reagent

The synthesis of arylboronic ester derivatives from aryl chlorides by using aryl(amino)boranes is described. Palladium-catalyzed coupling between aryl chlorides and diisopropylaminoborane leads to the formation of a C-B bond under mild conditions. A wide range of functional groups are tolerated, making this method particularly useful for the borylation of functionalized aromatics. Salts make the difference: The synthesis of arylboronic ester derivatives from aryl chlorides by using aryl(amino)boranes is described. Palladium-catalyzed coupling between aryl chlorides and diisopropylaminoborane leads to the formation of a C-B bond under mild conditions. A wide range of substituents, including electron-withdrawing groups, are tolerated (see scheme).

Nano-Fe2O3-catalyzed direct borylation of arenes

Nano-Fe2O3-catalyzed borylation of arenes with diboron pinacol ester B2pin2 has been found to give borylation products with selectivity controlled by electronic effects of substituents. The Royal Society of Chem