1073353-55-5

Basic information

• Product Name: 4-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID, PINACOL ESTER
• Synonyms: 4-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID, PINACOL ESTER;1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOYL]PYRROLIDINE;4-(PYRROLIDINE-1-CARBONYL)BENZENEBORONIC ACID PINACOL ESTER;4-Pyrrolidinylcarbonylphenylboronic acid, pinacol ester;Pyrrolidin-1-yl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone;1-pyrrolidinyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone;[4-[(1-Pyrrolidinyl)carbonyl]phenyl]boronic acid pinacol ester
• CAS NO: 1073353-55-5
• Molecular Formula: C₁₇H₂₄BNO₃
• Molecular Weight: 301.19
• Mol File: 1073353-55-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 442.4±28.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.31±0.20(Predicted)
• CAS DataBase Reference: 4-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID, PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID, PINACOL ESTER(1073353-55-5)
• EPA Substance Registry System: 4-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID, PINACOL ESTER(1073353-55-5)

Safety Data

• Hazardous Substances Data: 1073353-55-5(Hazardous Substances Data)

Usage

General Description

4-(Pyrrolidine-1-carbonyl)phenylboronic acid, pinacol ester is a chemical compound that is used in organic synthesis and pharmaceutical research. It is a boronic acid derivative with a pyrrolidine-1-carbonyl and phenyl group attached to the boron atom. The pinacol ester moiety provides stability to the boronic acid group, making it an important reagent for Suzuki-Miyaura coupling reactions, which are widely used in the synthesis of biaryl compounds. This chemical has demonstrated potential in the development of new pharmaceuticals and has applications in medicinal chemistry and drug discovery. Its unique structure and reactivity make it a valuable tool in the field of organic chemistry.

Upstream product

• 586-76-5 4-Bromobenzoic acid 
• 5543-27-1 4-(pyrrolidinocarbonyl)phenyl bromide 
• 73183-34-3 bis(pinacol)diborane 
• 14047-29-1 4-carboxyphenylboronic acid 
• 123-75-1 pyrrolidine 
• 180516-87-4 4-carboxyphenylboronic acid pinacol ester 

Downstream Products

• 1395316-14-9 3-bromo-5-(2-methoxy-ethoxymethoxy)-4-[4-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one 
• 1374457-20-1 3-bromo-5-hydroxy-4-[4-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one 
• 1620483-43-3 C₂₉H₂₈FN₃O₅ 
• 1620483-71-7 C₂₇H₂₆FN₃O₃ 
• 1620483-68-2 C₃₃H₂₄F₆N₂O₄ 
• 1620483-74-0 C₂₇H₂₅FN₂O₄ 

Relevant articles and documents

Pyridoazepine derivative, pharmaceutical composition and applications thereof

The present invention discloses a pyridoazepine derivative, a pharmaceutical composition and applications thereof, wherein the pyridoazepine derivative (I), the isomer, the prodrug, the stable isotopederivative or the pharmaceutically acceptable salt thereof have the following structure. According to the present invention, the pyridoazepine derivative has good regulatory effects on TLR family andrelated signaling pathways, particularly on TLR8, can effectively treat, alleviate and/or prevent various diseases mediated by signaling pathways related to TLR family and TLR, and particularly can effectively treat, alleviate and/or prevent various TLR8 mediated diseases such as cancers, autoimmune diseases, infections, inflammations, transplant rejections, graft versus host diseases and the like. The formula (I) is defined in the specification.

Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1

Microsomal prostaglandin E2 synthase-1 (mPGES-1) has been recognized as novel, promising drug target for anti-inflammatory and anticancer drugs. mPGES-1 catalyzes the synthesis of the inducible prostaglandin E 2 in response to pro-inflammatory stimuli, rendering this enzyme extremely interesting in drug discovery process owing to the drastic reduction of the severe side effects typical for traditional non-steroidal anti-inflammatory drugs. In the course of our investigations focused on this topic, we identified two interesting molecules bearing the γ- hydroxybutenolide scaffold which potently inhibit the activity of mPGES-1. Notably, the lead compound 2c that inhibited mPGES-1 with IC50 = 0.9 μM, did not affect other related enzymes within the arachidonic acid cascade.