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1073354-07-0

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1073354-07-0 Usage

General Description

The chemical "2-(1,3-Dioxolan-2-yl)ethylboronic acid pinacol ester" is a boronic acid derivative used in organic synthesis and medicinal chemistry. It is commonly used as a reagent for the Suzuki-Miyaura cross-coupling reaction, a widely used method for the formation of carbon-carbon bonds. 2-(1,3-Dioxolan-2-yl)ethylboronic acid pinacol ester contains a boronic acid group, which is known for its ability to form stable complexes with diols and other Lewis bases. The pinacol ester moiety provides stability to the boronic acid group and can be easily removed under mild conditions, making it a versatile building block for the synthesis of complex molecules. Due to its reactivity and versatility, this compound is widely used in the pharmaceutical and agrochemical industries for the synthesis of various biologically active compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 1073354-07-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,3,3,5 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1073354-07:
(9*1)+(8*0)+(7*7)+(6*3)+(5*3)+(4*5)+(3*4)+(2*0)+(1*7)=130
130 % 10 = 0
So 1073354-07-0 is a valid CAS Registry Number.

1073354-07-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2-(1,3-Dioxolan-2-yl)ethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1.2 Other means of identification

Product number -
Other names 2-[2-(1,3-dioxolan-2-yl)ethyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1073354-07-0 SDS

1073354-07-0Downstream Products

1073354-07-0Relevant articles and documents

Complex Boron-Containing Molecules through a 1,2-Metalate Rearrangement/anti-SN2′ Elimination/Cycloaddition Reaction Sequence

Tillin, Chloe,Bigler, Raphael,Calo-Lapido, Renata,Collins, Beatrice S.L.,Noble, Adam,Aggarwal, Varinder K.

, p. 449 - 453 (2019)

The three-component coupling of benzylamines, boronic esters, and 4-phenyl-3 H -1,2,4-triazole-3,5(4 H)-dione (PTAD) is reported. The boronate complex formed from an ortho -lithiated benzylamine and a boronic ester undergoes a stereospecific 1,2-metalate rearrangement/ anti -S N 2′ elimination in the presence of an N-activator to provide a dearomatized tertiary boronic ester. Interception of this dearomatized intermediate with a dienophile leads to stereopredictable cycloaddition reactions to generate highly complex three-dimensional boron-containing molecular structures. When enantioenriched α-methyl-substituted benzylamines are employed, the corresponding cycloaddition adducts are formed with excellent enantiospecificities.

Enantiospecific Synthesis of ortho-Substituted Benzylic Boronic Esters by a 1,2-Metalate Rearrangement/1,3-Borotropic Shift Sequence

Aichhorn, Stefan,Bigler, Raphael,Myers, Eddie L.,Aggarwal, Varinder K.

supporting information, p. 9519 - 9522 (2017/07/25)

Coupling reactions between benzylamines and boronic esters have been investigated. ortho-Lithiated benzylamines react with boronic esters and a N-activator to afford ortho-substituted benzylic boronic esters with formal 1,1′-benzylidene insertion into the C-B bond. The reaction occurs by a SN2′ elimination and 1,2-metalate rearrangement of the N-activated boronate complex to afford a dearomatized intermediate, which undergoes a Lewis-acid catalyzed 1,3-borotropic shift to afford the boronic ester products in high yield and with excellent enantiospecificity. The use of enantioenriched α-substituted benzylamines gave the corresponding secondary boronic esters with high ee.

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