1073354-14-9

Basic information

• Product Name: 2-FORMYLPYRIDINE-5-BORONIC ACID PINACOLATE
• Synonyms: 5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE-2-CARBALDEHYDE;2-FORMYL-5-PYRIDINE BORONIC ACID PINACOL ESTER;2-FORMYLPYRIDINE-5-BORONIC ACID PINACOLATE;2-FORMYLPYRIDINE-5-BORONIC ACID PINACOL ESTER;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-carbaldehyde;2-dioxaborolan-2-yl)pyridine-2-carbaldehyde;5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxaldehyde, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde
• CAS NO: 1073354-14-9
• Molecular Formula: C₁₂H₁₆BNO₃
• Molecular Weight: 233.07
• Product Categories: API intermediates;Organoborons;Pyridine
• Mol File: 1073354-14-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 345.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.10±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.71±0.12(Predicted)
• CAS DataBase Reference: 2-FORMYLPYRIDINE-5-BORONIC ACID PINACOLATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FORMYLPYRIDINE-5-BORONIC ACID PINACOLATE(1073354-14-9)
• EPA Substance Registry System: 2-FORMYLPYRIDINE-5-BORONIC ACID PINACOLATE(1073354-14-9)

Safety Data

• Hazardous Substances Data: 1073354-14-9(Hazardous Substances Data)

Usage

General Description

2-Formylpyridine-5-boronic acid pinacolate is a chemical compound with the molecular formula C12H15BNO4. It is commonly used as a reagent in organic synthesis and as a building block in the preparation of various pharmaceuticals and agrochemicals. 2-FORMYLPYRIDINE-5-BORONIC ACID PINACOLATE is a versatile and valuable intermediate in the production of complex organic molecules due to its ability to undergo a variety of chemical reactions, including cross-coupling reactions and Suzuki-Miyaura coupling. It is also utilized in the development of novel materials and catalysts. 2-Formylpyridine-5-boronic acid pinacolate is a pale yellow solid that is soluble in organic solvents and is typically stored and handled under inert gas conditions to prevent degradation.

Upstream product

• 31181-90-5 5-bromo-pyridine-2-carbaldehyde 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1426531-58-9 N-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenyl)-7-(6-(((2-hydroxyethyl)(methyl)amino)methyl)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426531-59-0 N-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenyl)-7-(6-formylpyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1245906-61-9 potassium (6-formylpyridin-3-yl)trifluoroborate 

Relevant articles and documents

1-CYANO-PYRROLIDINE DERIVATIVES AS DUB INHIBITORS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The novel compounds have formula (I): (Formula (I)) or are pharmaceutically acceptable salts thereof, wherein: R1a, R1b, R1c, R1d, R1e and R1f each independently represent hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C3-C4 cycloalkyl, or R1b and R1c together form an optionally substituted C3-C6 cycloalkyl ring, or R1d and R1e together form an optionally substituted C3-C6 cycloalkyl ring; R2 represents hydrogen or optionally substituted C1-C6 alkyl; A represents an optionally further substituted 5 to 10 membered monocyclic or bicyclic heteroaryl, heterocyclyl or aryl ring; L represents a covalent bond or linker; B represents an optionally substituted 3 to 10 membered monocyclic or bicyclic heterocyclyl, heteroaryl, cycloalkyl or aryl ring; and when -A-L-B is at position x attachment to A is via a carbon ring atom of A, and either: A cannot be triazolopyridazinyl, triazolopyridinyl, imidazotriazinyl, imidazopyrazinyl or pyrrolopyrimidinyl; or B cannot be substituted with phenoxyl; or B cannot be cyclopentyl when L is an oxygen atom.