1073354-59-2 Usage
General Description
2-[4-(N-Boc)piperazin-1-yl]phenylboronic acid pinacol ester is a chemical compound with potential application in pharmaceutical and organic chemistry. It consists of a boronic acid functional group attached to a phenyl ring, along with a piperazine ring containing a Boc (tert-butoxycarbonyl) protecting group. The pinacol ester group at the boronic acid moiety provides stability and makes it suitable for use in various synthetic reactions. 2-[4-(N-Boc)piperazin-1-yl]phenylboronic acid pinacol ester can be used as a building block for the synthesis of biologically active compounds and as a ligand in catalytic processes. It has the potential to be used in the development of new drugs and in the production of fine chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 1073354-59-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,3,3,5 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1073354-59:
(9*1)+(8*0)+(7*7)+(6*3)+(5*3)+(4*5)+(3*4)+(2*5)+(1*9)=142
142 % 10 = 2
So 1073354-59-2 is a valid CAS Registry Number.
1073354-59-2Relevant articles and documents
Synthesis and structure–activity relationship studies of LLY-507 analogues as SMYD2 inhibitors
Zhang, Bin,Liao, Liping,Wu, Fan,Zhang, Fengcai,Sun, Zhongya,Chen, Haijun,Luo, Cheng
, (2020/10/12)
SET and MYND domain-containing protein 2 (SMYD2), a lysine methyltransferase, is reported to catalyze the methylation of lysine residues on histone and non-histone proteins. As a potential target for cancer therapy, there are several SMYD2 inhibitors are reported, LLY-507 as a cell-active inhibitor exhibits submicromolar potency against SMYD2 in several cancer cell lines. To know which structural fragment of LLY-507 is suitable for chemical modification, three sites are chosen for structure–activity relationship studies (SARs). Among our focused library, compounds 43 and 44 with amide link on site C showed reasonably improved potency indicating that modification on this fragment is more flexible and introduction of electrophilic warheads in this position might provide lysine-targeting covalent inhibitors for SMYD2.
