1073354-59-2 Usage
Uses
Used in Pharmaceutical Industry:
2-[4-(N-Boc)piperazin-1-yl]phenylboronic acid pinacol ester is used as a building block for the synthesis of biologically active compounds due to its versatile chemical structure and reactivity, facilitating the creation of new drugs with potential therapeutic benefits.
Used in Organic Chemistry:
2-[4-(N-Boc)piperazin-1-yl]phenylboronic acid pinacol ester is used as a ligand in catalytic processes to enhance the efficiency and selectivity of chemical reactions, contributing to the advancement of synthetic methodologies in organic chemistry.
Used in Fine Chemicals Production:
2-[4-(N-Boc)piperazin-1-yl]phenylboronic acid pinacol ester is utilized in the production of fine chemicals, where its unique properties can be harnessed to create high-value specialty chemicals for various applications, including but not limited to, fragrances, dyes, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 1073354-59-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,3,3,5 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1073354-59:
(9*1)+(8*0)+(7*7)+(6*3)+(5*3)+(4*5)+(3*4)+(2*5)+(1*9)=142
142 % 10 = 2
So 1073354-59-2 is a valid CAS Registry Number.
1073354-59-2Relevant academic research and scientific papers
Synthesis and structure–activity relationship studies of LLY-507 analogues as SMYD2 inhibitors
Zhang, Bin,Liao, Liping,Wu, Fan,Zhang, Fengcai,Sun, Zhongya,Chen, Haijun,Luo, Cheng
, (2020/10/12)
SET and MYND domain-containing protein 2 (SMYD2), a lysine methyltransferase, is reported to catalyze the methylation of lysine residues on histone and non-histone proteins. As a potential target for cancer therapy, there are several SMYD2 inhibitors are reported, LLY-507 as a cell-active inhibitor exhibits submicromolar potency against SMYD2 in several cancer cell lines. To know which structural fragment of LLY-507 is suitable for chemical modification, three sites are chosen for structure–activity relationship studies (SARs). Among our focused library, compounds 43 and 44 with amide link on site C showed reasonably improved potency indicating that modification on this fragment is more flexible and introduction of electrophilic warheads in this position might provide lysine-targeting covalent inhibitors for SMYD2.
