1073524-90-9Relevant articles and documents
Novel synthesis and pharmacological evaluation as α2-adrenoceptor ligands of O-phenylisouronium salts
Goonan, Aine,Kahvedzic, Amila,Rodriguez, Fernando,Nagle, Padraic S.,McCabe, Thomas,Rozas, Isabel,Erdozain, Amaia M.,Javier Meana,Callado, Luis F.
experimental part, p. 8210 - 8217 (2009/04/11)
The synthesis of nine new mono- and bis-O-phenylisouronium compounds (2, 6b-10b and 12b-14b) and their Boc-protected isourea precursors (2a, 6a-10a and 12a-14a) is described. The carbodiimide 4, which was formed, had been suggested as the reactive intermediate species and driving force of the reaction. All final substrates were tested as potential α2-ARs ligands in human brain tissue by means of radioligand binding experiments and were compared to the potential antidepressant 1, as well as other related guanidine containing derivatives.