1073633-07-4Relevant academic research and scientific papers
Synthesis of medicinally interesting polyfluoro ketones via perfluoroalkyl lithium reagents
Kokotos, Christoforos G.,Baskakis, Constantinos,Kokotos, George
experimental part, p. 8623 - 8626 (2009/04/11)
(Chemical Equation Presented) The addition of (pentafluoroethyl)- and (heptafluoropropy-1)lithium to various acyl derivatives was studied. Weinreb and morpholine amides led to polyfluoro ketones in high to quantitative yields in short reaction times. Derivatives of 2-fluorocarboxylic acids may produce 1,1,1,2,2,4-hexafluoro ketones and 1,1,1,2,2,3,3,5-octafluoro ketones. The methodology can provide inhibitors for various lipolytic enzymes, including phospholipase A2.
