107378-31-4

Basic information

• Product Name: 2-(2-Oxo-2-phenyl-acetylamino)-propionamide
• CAS NO: 107378-31-4
• Molecular Weight: 220.228
• Mol File: 107378-31-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-Oxo-2-phenyl-acetylamino)-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Oxo-2-phenyl-acetylamino)-propionamide(107378-31-4)
• EPA Substance Registry System: 2-(2-Oxo-2-phenyl-acetylamino)-propionamide(107378-31-4)

Safety Data

• Hazardous Substances Data: 107378-31-4(Hazardous Substances Data)

Upstream product

• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 4726-84-5 alanine amide 

Downstream Products

• 107378-39-2 Acetic acid 5-acetoxy-6-methyl-3-phenyl-pyrazin-2-yl ester 
• 107378-34-7 3-methyl-6-phenyl-2,5-dihydroxypyrazine 
• 72876-00-7 2,5-dichloro-3-methyl-6-phenyl-pyrazine 

Relevant articles and documents

Studies on Pyrazines. 14. The Syntheses of 2,5-Dihydroxypyrazines and Their Derivatives

Reaction of phenylglycinamide (1c) with ethyl benzoylformate (2c) in the presence of refluxing ethanolic sodium ethoxide gave 2,5-dihydroxy-3,6-diphenylpyrazine (3i) in 19percent yield.This synthetic method, howewer, was limited to the preparation of 3i.On the other hand, α-aminoamides 1 condensed with α-ketoesters 2 to give the intermediates 5, which were also prepared by condensation of 1 with α-ketalesters 6, followed by hydrolysis of the ketal moeity.Cyclization of 5 with refluxing methanolic sodium methoxide gave only disubstituted 2,5-dihydroxypyrazines 3.Acetylation of 5 with refluxing acetic anhydride/acetic acid led to direct formation of 2,5-diacetoxypyrazines 9.Similarly, compounds 5 could be converted into 2,5-dichloropyrazines 4.