1073819-06-3Relevant articles and documents
Significant enhancement in radical-scavenging activity of curcuminoids conferred by acetoxy substituent at the central methylene carbon
Kim, Mi Kyoung,Jeong, Wooseong,Kang, Jihoon,Chong, Youhoon
, p. 3793 - 3800 (2011)
For a compound to be a radical-trapping antioxidant, the antioxidant-derived radical must be sufficiently inert to molecular oxygen as this would generate harmful chain-propagating peroxyl radicals. Curcumin has a unique structure with phenolic hydroxyl g
Design, synthesis and evaluation of curcumin-based fluorescent probes to detect Aβ fibrils
Sato, Taki,Hotsumi, Mayumi,Makabe, Koki,Konno, Hiroyuki
, p. 3520 - 3525 (2018)
Amyloid β fibrillation is an early event in Alzheimer's disease, so its detection is important to understand its roles in Alzheimer's disease. Curcumin, which has poor water solubility, has been reported to have many pharmacological activities including potent anti-amyloid β fibril activity in Alzheimer's disease. In this study, we found that curcumin analogues with the fluorescence property instead of non-inhibition of amyloid β fibrils. The development of new curcumin analogue, Me-CUR (9), as fluorescent switchable probe to detect amyloid β fibrils is described. Me-CUR (9) shows excellent fluorescence, especially higher than ThT (4), in the presence of amyloid β fibrils. These results suggest that Me-CUR (9) can become a useful in vitro amyloid fluorescence sensor for diagnosis of Alzheimer's disease.
CURCUMIN DERIVATIVE
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Paragraph 0039; 0046; 0047; 0048, (2018/10/19)
PROBLEM TO BE SOLVED: To provide a new curcumin derivative. SOLUTION: A chemical compound is shown by formula (1) as follows. In the formula, R1 is a 1-5C alkyl group, a 2-5C alkenyl group or a 2-5C alkynyl group; R2 is a 1-5C alkyl group, a 2-5C alkenyl group or a 2-5C alkynyl group; n1 is an integral number of 1-4, and when n1 is 2 or more, R1 may be the same or different from each other; and n2 is an integral number of 1-4, and when n2 is 2 or more, R2 may be the same or different from each other. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2018,JPOandINPIT