107383-65-3

Usage

Structure

Pyridinone derivative with a thioether group attached to the 3-position of the pyridinone ring

Potential applications

Pharmaceuticals and agrochemicals

Biological activities

Antioxidant, antimicrobial, and anti-inflammatory properties

Further research needed

To explore potential uses and properties.

Upstream product

• 13466-43-8 3-bromopyridin-2(1H)-one 
• 106-45-6 para-thiocresol 

Downstream Products

• 141667-61-0 1-(methanesulfonyl)-3-(4'-methylbenzenesulfenyl)-2-pyridone 
• 141667-32-5 3-(4-methylbenzenesulfenyl)-1-(4'-methylbenzenesulfonyl)-2-pyridone 
• 141667-51-8 5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene 
• 141667-52-9 methyl <<(tert-butyldimethylsilyl)oxy>methyl>-4β-<(4'-methylbenzenesulfonyl)amino>cyclohexene-1-carboxylate 
• 141667-47-2 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde 
• 141667-49-4 5-endo-(hydroxymethyl)-4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene 
• 141667-48-3 5-methyl-4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde 
• 141667-50-7 5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene 
• 141725-50-0 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-exo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene 
• 141667-46-1 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-endo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene 

Relevant academic research and scientific papers

Silver-Catalyzed Enantioselective Sulfimidation Mediated by Hydrogen Bonding Interactions

An enantioselective sulfimidation of 3-thiosubstituted 2-quinolones and 2-pyridones was achieved with a stoichiometric nitrene source (PhI=NNs) and a silver-based catalyst system. Key to the success of the reaction is the use of a chiral phenanthroline ligand with a hydrogen bonding site. The enantioselectivity does not depend on the size of the two substituents at the sulfur atom but only on the binding properties of the heterocyclic lactams. A total of 21 chiral sulfimides were obtained in high yields (44–99 %) and with significant enantiomeric excess (70–99 % ee). The sulfimidation proceeds with high site-selectivity and can also be employed for the kinetic resolution of chiral sulfoxides. Mechanistic evidence suggests the intermediacy of a heteroleptic silver complex, in which the silver atom is bound to one molecule of the chiral ligand and one molecule of an achiral 1,10-phenanthroline. Support for the suggested reaction course was obtained by ESI mass spectrometry, DFT calculations, and a Hammett analysis.