1073897-00-3

Upstream product

• 1073897-10-5 C₂₉H₄₈O₈SSi₂ 

Downstream Products

• 1025510-62-6 (+)-2-(1-hydroxy-5-triethylsilyloxy-1,5-dimethylhexyl)-5-(2-trimethylsilylethoxymethoxymethyl)phenol 
• 1025510-61-5 (+)-6-triethylsilyloxy-6-methyl-2-[2-(2-trimethylsilylethoxymethoxy)-4-(2-trimethylsilylethoxymethoxymethyl)phenyl]heptan-2-ol 
• 1073897-13-8 (+)-2-(1-hydroxy-1,5-dimethylhexyl)-5-(2-trimethylsilylethoxymethoxymethyl)phenol 
• 1073897-12-7 (+)-6-methyl-2-[2-(2-trimethylsilylethoxymethoxy)-4-(2-trimethylsilylethoxymethoxymethyl)phenyl]heptan-2-ol 

Relevant academic research and scientific papers

First asymmetric total synthesis of (+)-curcutetraol

The first asymmetric total synthesis of (+)-curcutetraol, a marine phenolic bisabolane-type sesquiterpene, was achieved in eight steps in ca. 50% overall yield. The chiral tertiary benzylic alcohol moiety in the o-position of a phenol was constructed in high optical yield (99% ee) by an asymmetric synthesis using a chiral aminal, (2R,5S)-2-methoxycarbonyl-3-phenyl-1,3-diazabicyclo[3.3.0]octane.

Asymmetric total synthesis of (+)-curcutetraol and (+)-sydonol

The asymmetric total syntheses of (+)-curcutetraol and (+)-sydonol, phenolic bisabolane-type sesquiterpenoids having chiral tertiary alcohol moiety in the o-position of a phenol, were achieved in high enantiomeric excesses (99% ee). The chiral tertiary benzylic alcohol moiety of these compounds was constructed by an asymmetric synthesis using an easily available chiral aminal, (-)-(2R,5S)-2-methoxycarbonyl-3-phenyl-1,3-diazabicyclo[3.3.0]octane. The absolute configurations of both (+)-curcutetraol and?(+)-sydonol have been assumed to be S-configuration based on the stereochemical course of the well established asymmetric synthesis used in the syntheses.