1073897-83-2Relevant articles and documents
Characterization and quantification of hydroxycinnamate derivatives in Stevia rebaudiana leaves by LC-MSn
Karakoese, Hande,Jaiswal, Rakesh,Kuhnert, Nikolai
experimental part, p. 10143 - 10150 (2012/01/13)
Stevia rebaudiana leaves are used as a zero-calorie natural sweetener in a variety of food products in Asian countries, especially in Japan. In this study, the hydroxycinnamate derivatives of S. rebaudiana have been investigated qualitatively and quantita
Structure-activity relationship of caffeoylquinic acids on the accelerating activity on ATP production
Miyamae, Yusaku,Kurisu, Manami,Han, Junkyu,Isoda, Hiroko,Shigemori, Hideyuki
, p. 502 - 507 (2011/06/10)
Caffeoylquinic acid (CQA) is one of the phenylpropanoids which have various bioactivities such as antioxidant, antibacterial, anticancer, antihistamic, and other biological effects. We previously reported that 3,5-di-O-caffeoylquinic acid inhibited amyloid β1-42-induced cellular toxicity on human neuroblastoma SH-SY5Y cells and increased the mRNA expression level of glycolytic enzymes and the intracellular ATP level. To investigate structure-activity relationship on the accelerating activity on ATP production, we synthesized 1,4,5-tri-O-caffeoylquinic acid, 4,5-di-O-caffeoylquinic acid, 3,4,5-tri-O-caffeoylquinic acid, and other derivatives. Additionally, we evaluated intracellular ATP level in SH-SY5Y treated with each CQA derivative. As a result, 3,4,5-tri-O-caffeoylquinic acid showed the highest accelerating activity on ATP production among tested compounds. It was suggested that caffeoyl groups bound to quinic acid are important for activity and the more caffeoyl groups are bound to quinic acid, the higher accelerating activity on ATP production exhibits.
