1073903-10-2Relevant academic research and scientific papers
In situ assembled boronate ester assisted chiral carboxylic acid catalyzed asymmetric trans-aziridinations
Hashimoto, Takuya,Galvez, Alberto Osuna,Maruoka, Keiji
supporting information, p. 17667 - 17670 (2014/01/06)
We developed herein a new chiral Bronsted acid catalyst which is composed of two independent organic molecules, a chiral diol, and 2-boronobenzoic acid. In situ formation of a boronate ester was utilized as a key process to generate an active catalyst. This boronate ester assisted chiral carboxylic acid catalyst was successfully applied to the trans-aziridination of N-Boc and N-benzyl imines with N-phenyldiazoacetamide. This is the first catalyst to achieve high enantioselectivities using N-benzyl imines.
Trans-selective asymmetric aziridination of diazoacetamides and N-Boc imines catalyzed by axially chiral dicarboxylic acid
Hashimoto, Takuya,Uchiyama, Nanase,Maruoka, Keiji
supporting information; scheme or table, p. 14380 - 14381 (2009/02/08)
Axially chiral dicarboxylic acid (R)-1d catalyzed reaction of diazoacetamides and N-Boc imines provided a novel organocatalytic means for the formation of enantiomerically enriched N-Boc protected trans aziridines. Copyright
