1073927-63-5

Basic information

• Product Name: 5-methyl-4-phenyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazolium perchlorate
• CAS NO: 1073927-63-5
• Molecular Weight: 424.76
• Mol File: 1073927-63-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-methyl-4-phenyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazolium perchlorate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-4-phenyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazolium perchlorate(1073927-63-5)
• EPA Substance Registry System: 5-methyl-4-phenyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazolium perchlorate(1073927-63-5)

Safety Data

• Hazardous Substances Data: 1073927-63-5(Hazardous Substances Data)

Upstream product

• 1682-20-8 2,3,5,6-tetrafluoropyridin-4-amine 
• 135826-71-0 (Z)-2-Phenyl-3-thiocyanato-but-2-enal 

Downstream Products

• 1073927-81-7 C₁₅H₈F₄N₂O₃S 

Relevant articles and documents

Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides

The synthesis of a series of new isothiazol-3(2H)-one 1,1-dioxides with halogenated (mostly fluorinated) pyridinyl and pentafluorophenyl substituents at 2-position is reported. These compounds (18-24) became easily accessible from 2-thiocyanato-1-carboxaldehydes and aminopyridines, pentafluoroaniline, respectively, by an isothiazolium cyclization-oxidation route. Compound 21 exhibited an IC50 value of 3.1 μM toward human leukocyte elastase. The proteases cathepsin G, trypsin, cathepsin L, and angiotensin-converting enzyme, and the serine esterases acetylcholinesterase and cholesterol esterase were not inhibited by 21.