1073950-83-0

Basic information

• Product Name: 2-[(2,5-difluorophenyl)amino]-3-(2-oxopropyl)isoindolin-1-one
• Synonyms: 2-[(2,5-difluorophenyl)amino]-3-(2-oxopropyl)isoindolin-1-one
• CAS NO: 1073950-83-0
• Molecular Weight: 316.307
• Mol File: 1073950-83-0.mol

Chemical Properties

• CAS DataBase Reference: 2-[(2,5-difluorophenyl)amino]-3-(2-oxopropyl)isoindolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2,5-difluorophenyl)amino]-3-(2-oxopropyl)isoindolin-1-one(1073950-83-0)
• EPA Substance Registry System: 2-[(2,5-difluorophenyl)amino]-3-(2-oxopropyl)isoindolin-1-one(1073950-83-0)

Safety Data

• Hazardous Substances Data: 1073950-83-0(Hazardous Substances Data)

Upstream product

• 76293-36-2 4-(2-iodophenyl)but-3-en-2-one 
• 201230-82-2 carbon monoxide 
• 97108-50-4 (2,5-difluorophenyl)hydrazine 

Relevant articles and documents

Regioselective synthesis of N-aminoisoindolones and mono-N- and di-N,N′-substituted phthalazones utilizing hydrazine nucleophiles in a palladium-catalyzed three-component cascade process

(Chemical Equation Presented) A palladium-catalyzed three-component cascade process for the synthesis of isoindolone and phthalazone derivatives is reported. The cascade process involves carbonylation of an aryl iodide/Michael acceptor to give an acylpalladium species which is intercepted by a hydrazine nucleophile. Intramolecular Michael addition follows to give either N-aminoisoindolones or mono-N- and di-N,N′-phthalazones depending on whether a monosubstituted or 1,2-disubstituted hydrazine nucleophile is used.