1074-36-8

Basic information

• Product Name: 4-Mercaptobenzoic acid
• Synonyms: 4-MERCAPTOBENZOIC ACID;P-MERCAPTO BENZOIC ACID;4-Carboxybenzenethiol;4-Sulfanylbenzoic acid;Benzoic acid, p-mercapto-;p-Mercaptobenzoic Acid 4-Mercaptobenzoic Acid;Mercaptobenzoicacid,4-;4-Mercaptobenzoic Acid, Technical Grade
• CAS NO: 1074-36-8
• Molecular Formula: C₇H₆O₂S
• Molecular Weight: 154.19
• EINECS: 205-704-3
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Phenol&Thiophenol&Mercaptan;Organic acids;Aromatics Compounds;Aromatics;Sulfur & Selenium Compounds;Organic Building Blocks;Sulfur Compounds;Thiols/Mercaptans;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds
• Mol File: 1074-36-8.mol
• Article Data: 24

Chemical Properties

• Melting Point: 215-224 °C(lit.)
• Boiling Point: 314.278 °C at 760 mmHg
• Flash Point: 143.871 °C
• Appearance: Cream colour crystalline solid
• Density: 1.346 g/cm³
• Vapor Pressure: 0.0112mmHg at 25°C
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: soluble in Alcohol,Ether
• PKA: 4.05±0.10(Predicted)
• Stability: Store Under Argon; Air and Temperature Sensitive
• CAS DataBase Reference: 4-Mercaptobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Mercaptobenzoic acid(1074-36-8)
• EPA Substance Registry System: 4-Mercaptobenzoic acid(1074-36-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 3335
• WGK Germany: 3
• Hazardous Substances Data: 1074-36-8(Hazardous Substances Data)

Usage

Chemical Properties

Cream Colour Crystalline Solid

Uses

Gold nanostructures functionalized with 4-Mercaptobenzoic acid (4-MBA) may exhibit improve catalytic activity. Several studies report 4-MBA as a model analyte for surface enhancement Raman scattering (SERS) substrates.

General Description

4-mercaptobenzoic acid (4-MBA) is a probe molecule with thiol and carboxylic groups that form a self-assembled monolayers (SAMs) which can be used for the development of surface enhanced raman spectroscopy (SERS) sensors.

InChI:InChI=1/C7H6O2S/c8-7(9)5-1-3-6(10)4-2-5/h1-4,8-9H/p-2

Synthetic route

4-iodobenzoic acid (619-58-9) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With sodiumsulfide nonahydrate; copper; ethane-1,2-dithiol In dimethyl sulfoxide at 90℃; for 12h; Inert atmosphere; Sealed tube;	99%
With sodiumsulfide nonahydrate; copper; ethane-1,2-dithiol In dimethyl sulfoxide at 100℃; for 20h; Inert atmosphere; Green chemistry;	99%
With copper(ll) sulfate pentahydrate; ethane-1,2-dithiol; potassium hydroxide In water; dimethyl sulfoxide at 90℃; for 20h; Inert atmosphere;	94%
With copper(l) iodide; thiourea; L-proline; sodium t-butanolate In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere;	90%
Stage #1: 4-iodobenzoic acid With copper(l) iodide; potassium carbonate; sulfur In N,N-dimethyl-formamide at 90℃; for 16h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In N,N-dimethyl-formamide at 40℃; Inert atmosphere; Cooling with ice;	87%

S-(4-carbomethoxyphenyl) N,N-dimethylthiocarbamate (13511-93-8) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With sodium hydroxide In methanol; water for 3h; Heating;	97%
With potassium hydroxide In methanol; water	2.7 g
With potassium hydroxide In methanol

S-acetyl-4-mercaptobenzoic acid (24197-62-4) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With sodium thiomethoxide In methanol at 23℃; for 0.5h;	94%

4-mercaptobenzyl alcohol (53339-53-0) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With diethylene glycol dimethyl ether at 70℃; for 0.5h; Sonication;	94%
With oxygen at 120℃; for 16h; Green chemistry;	84%

4-Bromobenzoic acid (586-76-5) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With copper(ll) sulfate pentahydrate; ethane-1,2-dithiol; potassium hydroxide In water; dimethyl sulfoxide at 110℃; for 20h; Inert atmosphere;	91%
Multi-step reaction with 2 steps 1: copper(l) iodide; tetra(n-butyl)ammonium hydroxide; sulfur / water / 48 h / 80 °C / Inert atmosphere; Sealed tube 2: hydrogenchloride; zinc / water / Inert atmosphere; Cooling with ice View Scheme

C11H12O3S2 → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With potassium hydroxide In methanol at 20℃; for 18h;	78%

dimethyl 4,4'-dithiobisbenzoate (35190-68-2) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With acetic acid; zinc for 4h; Heating;	42%

4,4'-Dithiobisbenzoic acid (1155-51-7) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With acetic acid; zinc for 4h; Heating;	38%
With triphenylphosphine In 1,4-dioxane; water at 30℃; Rate constant;
With sodium carbonate; aluminium

p-carboxyphenylsulfonyl chloride (10130-89-9) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With acetic acid; zinc at 90 - 100℃;
With acetic acid; zinc

potassium ethyl xanthogenate (140-89-6) + 4-amino-benzoic acid (150-13-0) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With hydrogenchloride; water; sodium nitrite Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge;
With hydrogenchloride; sodium hydroxide; sodium nitrite In water; acetic acid

para-bromobenzenethiol (106-53-6) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With n-butyllithium; diethyl ether anschliessendes Behandeln mit Kohlendioxid;

4-amino-benzoic acid (150-13-0) → 4,4'-Dithiobisbenzoic acid (1155-51-7) + 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With hydrogenchloride; potassium ethyl xanthogenate; sodium nitrite Yield given. Multistep reaction. Yields of byproduct given;

C12H17N2O2S(1+)*I(1-) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With buffer (pH=11) at 20℃;
With buffer (pH=11) at 20℃; Rate constant;

para-chlorobenzoic acid (74-11-3) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With sodium tetrahydroborate; sulfur 1.) 340 deg C, NaOH-KOH melt, 3 min.; 2.) water; Yield given. Multistep reaction;

3-chlorobenzoate (535-80-8) → 4-mercaptobenzoic acid (1074-36-8) + 3-mercapto benzoic acid (4869-59-4)

Conditions	Yield
With sodium tetrahydroborate; sulfur 1.) 360 deg C, NaOH-KOH melt, 3 min.; 2.) water; Yield given. Multistep reaction. Yields of byproduct given;

4-amino-benzoic acid (150-13-0) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
(i) aq. HCl, NaNO2, (ii) potassium ethyl xanthate, (iii) KOH, EtOH; Multistep reaction;

4,4'-Dithiobisbenzoic acid (1155-51-7) + iron powder + concentrated natrium carbonate → 4-mercaptobenzoic acid (1074-36-8)

hydrogenchloride (7647-01-0) + p-carboxyphenylsulfonyl chloride (10130-89-9) + acetic acid (64-19-7) + zinc → 4-mercaptobenzoic acid (1074-36-8)

C18H15NO4S → 4-mercaptobenzoic acid (1074-36-8) + methyl (E)-2-cyano-3-phenylprop-2-enoate (14533-86-9)

Conditions	Yield
In [D3]acetonitrile; water-d2 Equilibrium constant;

C17H14N2O3S → 4-mercaptobenzoic acid (1074-36-8) + (E)-2-cyano-3-phenylacrylamide (709-79-5, 148238-27-1, 15795-18-3)

Conditions	Yield
In [D3]acetonitrile; water-d2 Equilibrium constant;

C17H13ClN2O3S → 4-mercaptobenzoic acid (1074-36-8) + (E)-3-(2-chlorophenyl)-2-cyanoacrylamide (15804-58-7)

Conditions	Yield
In [D3]acetonitrile; water-d2 Equilibrium constant;

4-mercaptobenzaldehyde (91358-96-2) → 4-mercaptobenzoic acid (1074-36-8)

Conditions	Yield
With potassium permanganate In water; acetonitrile

4,4'-Dithiobisbenzoic acid (1155-51-7) + Ac-GGRCGW-NH2 → 4-mercaptobenzoic acid (1074-36-8) + C38H56N14O13S2

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. phosphate buffer; dimethyl sulfoxide / 0.5 h 2: pH 7.4 View Scheme

GLUTATHIONE (70-18-8) + C35H45N11O9S2 → 4-mercaptobenzoic acid (1074-36-8) + C38H56N14O13S2

Conditions	Yield
pH=7.4; chemoselective reaction;

C37H49N11O9S2 → 4-mercaptobenzoic acid (1074-36-8) + C30H45N11O7S

Conditions	Yield
With GLUTATHIONE pH=7.4;

4-mercaptobenzoic acid (1074-36-8) + 2,4-Diamino-5-ethylpyrrolo<2,3-d>pyrimidine (170170-14-6) → 4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoic acid (945452-29-9)

Conditions	Yield
With iodine In ethanol; water Heating;	100%

4-mercaptobenzoic acid (1074-36-8) → 4,4'-Dithiobisbenzoic acid (1155-51-7)

Conditions	Yield
Stage #1: 4-mercaptobenzoic acid With dihydrogen peroxide; triethylamine In methanol; water at 5 - 25℃; for 0.666667h; Stage #2: With hydrogenchloride In methanol; water at 5 - 25℃; for 1h;	99.5%
With iodine; triethylamine In ethanol for 16h;	98%
With manganese(II)carbonate; 3,4,5-trihydroxybenzoic acid; oxygen; sodium carbonate In water at 80℃; under 2250.23 Torr; for 4h; pH=9; Schlenk technique; Green chemistry;	98%

4-mercaptobenzoic acid (1074-36-8) → 4,4'-dicarboxydiphenyl sulfide (4919-48-6)

Conditions	Yield
With dihydrogen peroxide; triethylamine In methanol; water at 25℃; for 0.5h;	99.5%

2-chloro-1-[(2-iodophenyl)methyl]-1H-benzo[d]imidazole (895582-17-9) + 4-mercaptobenzoic acid (1074-36-8) → 4-({1-[(2-iodophenyl)methyl]-1H-benzo[d]imidazol-2-yl}sulfanyl)benzene-1-carboxylic acid (895582-08-8)

Conditions	Yield
With potassium tert-butylate In ethanol Heating;	99%

cis-3-(piperidin-1-yl)cyclobutyl 4-bromobenzenesulfonate (1174738-27-2) + 4-mercaptobenzoic acid (1074-36-8) → 4-{[trans-3-(piperidin-1-yl)cyclobutyl]sulfanyl}benzoic acid (1174737-87-1)

Conditions	Yield
Stage #1: 4-mercaptobenzoic acid With sodium thiosulfate In N,N-dimethyl-formamide for 1h; Molecular sieve; Stage #2: cis-3-(piperidin-1-yl)cyclobutyl 4-bromobenzenesulfonate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20 - 50℃; for 14h;	99%

4-mercaptobenzoic acid (1074-36-8) + 2,5-dibromobenzene-1,4-dinitrile (18870-11-6) → 4,4'-((2,5-dicyano-1,4-phenylene)bis(sulfanediyl))dibenzoic acid

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h; Inert atmosphere;	99%

2,3,5,6-tetrachloroterephthalonitrile (1897-41-2) + 4-mercaptobenzoic acid (1074-36-8) → 4,4',4'',4'''-((3,6-dicyanobenzene-1,2,4,5-tetrayl)tetrakis(sulfanediyl))-tetrabenzoic acid

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h; Inert atmosphere;	99%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 48h; Inert atmosphere;	35%

4-mercaptobenzoic acid (1074-36-8) + acetic anhydride (108-24-7) → S-acetyl-4-mercaptobenzoic acid (24197-62-4)

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 6h; Inert atmosphere;	98%
With pyridine	88%
With potassium hydroxide; acetic acid	79%
In pyridine at 0 - 20℃;

3,4-epoxyheptan-2-one (33667-08-2) + 4-mercaptobenzoic acid (1074-36-8) → rel-(3R,4R)-3-(4-carboxyphenylthio)-4-hydroxyheptan-2-one

Conditions	Yield
sodium hydroxide In water at 30℃; for 1h; pH=6.0;	98%

1-[2-(2-bromophenyl)ethyl]-2-chloro-1H-benzo[d]imidazole (895582-18-0) + 4-mercaptobenzoic acid (1074-36-8) → 4-{1-[2-(2-bromo-phenyl)-ethyl]-1H-benzoimidazol-2-ylsulfanyl}-benzoic acid (895582-09-9)

Conditions	Yield
With potassium tert-butylate In ethanol Heating;	98%

2-chloro-1-[(4-phenylselanyl)butyl]-1H-benzo[d]imidazole (895581-99-4) + 4-mercaptobenzoic acid (1074-36-8) → 4-({1-[(4-phenylselanyl)butyl]-1H-benzo[d]imidazol-2-yl}sulfanyl)benzoic acid (895582-02-2)

Conditions	Yield
	98%

2-chloro-1-[(5-phenylselanyl)pentyl]-1H-benzo[d]imidazole (895582-00-0) + 4-mercaptobenzoic acid (1074-36-8) → 4-({1-[(5-phenylselanyl)pentyl]-1H-benzo[d]imidazol-2-yl}sulfanyl)benzoic acid (895582-03-3)

Conditions	Yield
	98%

methanol (67-56-1) + 4-mercaptobenzoic acid (1074-36-8) → methyl 4-mercaptobenzoate (6302-65-4)

Conditions	Yield
With sulfuric acid Reflux;	97.7%
With sulfuric acid at 90℃; for 24h;	95%
With sulfuric acid for 15h; Reflux;	90%

4-mercaptobenzoic acid (1074-36-8) → 4-mercaptobenzyl alcohol (53339-53-0)

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 6h; Inert atmosphere;	97%
With lithium aluminium tetrahydride In tetrahydrofuran for 16.5h; Inert atmosphere; Reflux;	93%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 16h; Inert atmosphere;	82%

4-mercaptobenzoic acid (1074-36-8) + 2-bromoethanol (540-51-2) → 4-((2-hydroxyethyl)thio)benzoic acid (7184-99-8)

Conditions	Yield
Stage #1: 4-mercaptobenzoic acid With sodium hydroxide at 80℃; for 0.75h; Stage #2: 2-bromoethanol for 2h; Stage #3: With hydrogenchloride In water	97%
With triethylamine In sodium hydroxide; dichloromethane	34.21 g (56.7%)

4-mercaptobenzoic acid (1074-36-8) + isopropyl alcohol (67-63-0) → diisopropyl 4,4’-dithiobisbenzoate

Conditions	Yield
With thionyl chloride at 80℃; for 168h;	97%

2,3-epoxy-2-methyl-2,3-dihydro-1,4-naphthoquinone (15448-59-6, 61840-91-3, 82864-14-0, 105016-62-4) + 4-mercaptobenzoic acid (1074-36-8) → 2-(4-carboxyphenylthio)-3-methyl-1,4-naphthoquinone

Conditions	Yield
sodium hydroxide In water at 30℃; for 4h;	96%

4-mercaptobenzoic acid (1074-36-8) + tetrakis(pentafluorophenyl)porphyrin (25440-14-6) → 5,10,15,20-tetrakis(4-carboxyphenylthio-2,3,5,6-tetrafluorophenyl)porphyrin

Conditions	Yield
Stage #1: 4-mercaptobenzoic acid With pyridine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: tetrakis(pentafluorophenyl)porphyrin In N,N-dimethyl-formamide for 48h;	96%
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 1h;	80%

chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I) + 4-mercaptobenzoic acid (1074-36-8) → Au(SC6H4CO2H-4)(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)

Conditions	Yield
Stage #1: 4-mercaptobenzoic acid With potassium hydroxide In ethanol; water at 20℃; for 0.333333h; Stage #2: chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I) In ethanol; water at 20℃; for 5h;	96%
With sodium methylate In methanol; dichloromethane for 2h;	84%

4-mercaptobenzoic acid (1074-36-8) + 4,5-dichlorophthalonitrile (139152-08-2) → 4,4′-((4,5-dicyano-1,2-phenylene)bis(sulfanediyl))dibenzoic acid

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h; Inert atmosphere;	96%

di-tert-butyl dicarbonate (24424-99-5) + 4-mercaptobenzoic acid (1074-36-8) → 4-{[(tertbutoxy)carbonyl]sulfanyl}benzoic acid (396725-66-9)

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran at 20℃; for 3h;	95%
With dmap; triethylamine In tetrahydrofuran at 20℃;	82%

7-oxabicyclo[4.1.0]heptan-2-one (6705-49-3) + 4-mercaptobenzoic acid (1074-36-8) → 2-(4-carboxyphenylthio)cyclohex-2-en-1-one (681824-23-7)

Conditions	Yield
sodium hydroxide In water at 30℃; for 1h; pH=6.0;	95%

chalcone epoxide (5411-12-1) + 4-mercaptobenzoic acid (1074-36-8) → 4-((2-oxo-2-phenylethyl)thio)benzoic acid

Conditions	Yield
With cetyltrimethylammonium hydroxide In water at 30℃; for 12h;	95%

4-mercaptobenzoic acid (1074-36-8) + 2,4-Diamino-5-methylpyrrolo<2,3-d>pyrimidine (170170-13-5) → 4-(2,4-diamino-5-methylpyrrolo[2,3-d]pyrimidin-6-ylthio)benzoic acid (870754-12-4)

Conditions	Yield
With water; iodine In ethanol for 2h; Heating;	95%
Stage #1: 4-mercaptobenzoic acid; 2,4-Diamino-5-methylpyrrolo<2,3-d>pyrimidine In ethanol; water for 0.0833333h; Reflux; Stage #2: With iodine In ethanol; water for 3h; Reflux;

chloro-η(3)-(bis(diphenylphosphinoethyl)phenylphosphine)rhodium(I) (33847-53-9) + 4-mercaptobenzoic acid (1074-36-8) → (4-carboxybenzenethiolato)(bis(diphenylphosphanylethyl)phenylphosphane)rhodium(I) (918667-32-0)

Conditions	Yield
With N(CH2CH2CH2CH3)3 In tetrahydrofuran byproducts: (NH(CH2CH2CH2CH3)3)Cl; (N2); a soln. of ligand added over 30 min to a soln. of Rh complex and N(C4H9)3 at room temp., stirred overnight; evapd. (vac.), washed (toluene and n-hexane), dissolved in THF, pptd. (n-hexane), dried (vac.); elem. anal.;	95%

4-mercaptobenzoic acid (1074-36-8) + 4,4'-Dimethoxybenzhydrol (728-87-0) → 4-[bis(4-methoxyphenyl)methylthio]benzoic acid (1619971-19-5)

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0) In water at 80℃; for 1h; Sealed tube;	95%

1-Bromoheptane (629-04-9) + 4-mercaptobenzoic acid (1074-36-8) → 4-(heptylthio)benzoic acid (32910-58-0)

Conditions	Yield
With potassium hydroxide In ethanol for 12h; Williamson Ether Synthesis; Reflux;	95%

1-bromo-hexane (111-25-1) + 4-mercaptobenzoic acid (1074-36-8) → 4-(hexylthio)benzoic acid (22683-51-8)

Conditions	Yield
With potassium hydroxide In ethanol for 12h; Williamson Ether Synthesis; Reflux;	95%

Upstream product

• 10130-89-9 p-carboxyphenylsulfonyl chloride 
• 1155-51-7 4,4'-Dithiobisbenzoic acid 
• 140-89-6 potassium ethyl xanthogenate 
• 150-13-0 4-amino-benzoic acid 
• 74-11-3 para-chlorobenzoic acid 
• 619-58-9 4-iodobenzoic acid 
• 53339-53-0 4-mercaptobenzyl alcohol 
• 70-18-8 GLUTATHIONE 
• 91358-96-2 4-mercaptobenzaldehyde 
• 586-76-5 4-Bromobenzoic acid 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 24197-62-4 S-acetyl-4-mercaptobenzoic acid 
• 535-80-8 3-chlorobenzoate 

Downstream Products

• 28276-32-6 ethyl p-mercaptobenzoate 
• 101597-64-2 4,4'-propanediyldimercapto-di-benzoic acid 
• 71310-25-3 4-{2-[bis-(2-chloro-ethyl)-amino]-2-oxo-2λ⁵-[1,3,2]oxazaphosphinan-4-ylsulfanylmethyl}-benzoic acid 
• 7184-99-8 4-((2-hydroxyethyl)thio)benzoic acid 
• 74761-53-8 4-<(3-cyano-4-nitrophenyl)thio>benzoic acid 
• 16195-39-4 4-(allylthio)benzoic acid 
• 13205-48-6 4-(methylthio)benzoic acid 
• 3795-79-7 methyl 4-(methylthio)benzoate 
• 272777-28-3 4-[(2,2-diethoxyethyl)thio]benzoic acid 
• 926294-59-9 4-[(5-methylpyridin-2-yl)sulfanyl]benzoic acid 
• 926643-30-3 C₁₄H₁₁NO₃S 
• 346706-21-6 [Au(4-SC₆H₄CO₂H)]2(1,1'-bis(diphenylphosphino)ferrocene) 
• 400849-80-1 [Au(4-SC₆H₄CO₂H)(2,6-Me₂C₆H₃NC)] 
• 400849-79-8 [Au(4-SC₆H₄CO₂H)(tBuNC)] 

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4-Mercaptobenzoic acid (cas 1074-36-8) assisted synthesis of Au-decorated α-Fe2O3 nanopaticles with highly enhanced photocatalytic performance08/03/2019

A novel Au-decorated α-Fe2O3 nanocomposite has been successfully prepared using 4-mercaptobenzoic acid as bridging agent via a facile and cost-effective method. The formed 10 mol% Au-decorated α-Fe2O3 (Au/α-Fe2O3) nanocomposite demonstrates a narrower band gap (1.88 eV), 4.3 times larger phot...detailed

4-Mercaptobenzoic acid (cas 1074-36-8) modified silver nanoparticles-enhanced electrochemical sensor for highly sensitive detection of Cu2+08/02/2019

In this work, a novel metal-enhanced electrochemical sensor based on silver nanoparticles (AgNPs) signal amplification was presented for highly sensitive determination of Cu2+. Gold nanoparticles were electrochemically deposited on fluorine doped tin oxide, and then 4-mercaptobenzoic acid (MBA) ...detailed

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The preparation of bicyclic pyrrolidines, stable and easy to isolate, is performed through both classical solution chemistry and on solid support. A new linker strategy is presented based on the concept of REM resin approach. Starting from a suitably derivatized Wang's resin, the linker can be REgenerated after cleavage of the product and functionalized to start a new synthetic cycle via a Michael reaction. In the present work a vinyl sulfone supported on a Wang's resin is able to undergo a Michael reaction with an amino acid derivative; the obtained adduct serves as a precursor for azomethine ylide generation, which is conveniently trapped with N-methyl-maleimide. The results are presented and discussed in the light of the experimental conditions applied as well as the method chosen for the cleavage of the product and resin regeneration.

Method for synthesizing benzoic acid compound from benzyl alcohol compound by ultrasonic-assisted oxidation

The invention belongs to the field of synthesis of organic intermediates, and specifically discloses an ultrasonic-assisted synthesis method for a benzoic acid compound. The method comprises the following step: promoting air oxidation of benzyl alcohol by using diethylene glycol dimethyl ether under an ultrasonic-assisted action so as to obtain the benzoic acid compound, wherein a benzyl alcohol raw material is benzyl alcohol, or a benzoic acid derivative containing one to five substituents at different positions on the benzene ring of benzyl alcohol; and a reaction accelerator is the diethylene glycol dimethyl ether. The method provided by the invention has the advantages of easily-available raw materials, simple and convenient reaction conditions, short reaction time, greenness, energy conservation, high reaction selectivity and yield, excellent compatibility of substrate functional groups, and high application value.