107408-19-5

Basic information

• Product Name: ethyl 2-acetyl-3-(2-bromophenyl)propionate
• Synonyms: ethyl 2-acetyl-3-(2-bromophenyl)propionate
• CAS NO: 107408-19-5
• Molecular Weight: 299.164
• Mol File: 107408-19-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: ethyl 2-acetyl-3-(2-bromophenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-acetyl-3-(2-bromophenyl)propionate(107408-19-5)
• EPA Substance Registry System: ethyl 2-acetyl-3-(2-bromophenyl)propionate(107408-19-5)

Safety Data

• Hazardous Substances Data: 107408-19-5(Hazardous Substances Data)

Upstream product

• 18982-54-2 o-bromobenzyl alcohol 
• 20444-11-5 2-bromo-1-(4-methylbenzenesulfonyloxymethyl)benzene 
• 141-97-9 ethyl acetoacetate 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 3506-68-1 4-(2-bromophenyl)-2-butanone 
• 112818-02-7 3-(2-acetylphenyl)propionic acid ethyl ester 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 1091602-32-2 C₁₇H₁₈BrN₃O₄S 
• 107408-52-6 4-(1-Methyl-indan-1-yl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-butyric acid ethyl ester 
• 107408-53-7 5-Methylene-3-oxo-7-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-heptanoic acid ethyl ester 

Relevant articles and documents

Assembly of 4H-chromenes, imidazobenzothiazines and quinazolines via copper-catalyzed domino reactions using 2-halobenzyl tosylates as substrates

The use of 2-halobenzyl tosylates as substrates in copper-catalyzed domino intermolecular substitution/intramolecular arylation processes for the efficient and selective preparation of heterocycles is reported for the first time. Reaction of 2-halobenzyl tosylates with β-ketoesters delivers 4H-chromenes with yields ranging between 59 and 89%. Imidazobenzothiazines are formed with yields up to 82% upon reaction of 2-halobenzyl tosylates with 2-mercaptoimidazoles. When 2-halobenzyl tosylates are reacted with benzamidines the corresponding quinazolines are obtained.

Microwave-assisted dealkoxycarbonylation of α-mono- and α,α-disubstituted β-keto- and α-cyanoesters mediated by a silica gel bed

A new alternative protocol for the classical Krapcho reaction is reported herein, involving a microwave-assisted method, which replaces the typical aprotic polar solvent with a silica gel support along with the addition of only a few μL of DMF to enhance

gem-Difluoroolefination of Diazo Compounds with TMSCF3 or TMSCF2Br: Transition-Metal-Free Cross-Coupling of Two Carbene Precursors

A new olefination protocol for transition-metal-free cross-coupling of two carbene fragments arising from two different sources, namely, a nonfluorinated carbene fragment resulting from a diazo compound and a difluorocarbene fragment derived from Ruppert-Prakash reagent (TMSCF3) or TMSCF2Br, has been developed. This gem-difluoroolefination proceeds through the direct nucleophilic addition of diazo compounds to difluorocarbene followed by elimination of N2. Compared to previously reported Cu-catalyzed gem-difluoroolefination of diazo compounds with TMSCF3, which possesses a narrow substrate scope due to a demanding requirement on the reactivity of diazo compounds and in-situ-generated CuCF3, this transition-metal-free protocol affords a general and efficient approach to various disubstituted 1,1-difluoroalkenes, including difluoroacrylates, diaryldifluoroolefins, as well as arylalkyldifluoroolefins. In view of the ready availability of diazo compounds and difluorocarbene reagents and versatile transformations of 1,1-difluoroalkenes, this new gem-difluoroolefination method is expected to find wide applications in organic synthesis.