107408-35-5Relevant articles and documents
Umpolung of Michael acceptors catalyzed by N-heterocyclic carbenes
Fischer, Christian,Smith, Sean W.,Powell, David A.,Fu, Gregory C.
, p. 1472 - 1473 (2006)
N-Heterocyclic carbenes can catalyze β-alkylations of a range of α,β-unsaturated esters, amides, and nitriles that bear pendant leaving groups to form a variety of ring sizes. In this process, the nucleophilic catalyst transiently transforms the normally electrophilic β carbon into a nucleophilic site through an unanticipated addition-tautomerization sequence. Copyright
Concise asymmetric synthesis of (-)-sparteine
Hermet, Jean-Paul R.,McGrath, Matthew J.,O'Brien, Peter,Porter, David W.,Gilday, John
, p. 1830 - 1831 (2007/10/03)
A six-step asymmetric synthesis of natural (-)-sparteine from ethyl 7-iodohept-2-enoate is reported, involving a connective Michael addition of an amino ester-derived enolate to an α,β-unsaturated amino ester.
N-(4-methylbenzenesulfonyl)- pyrrolidines and piperidines by a tandem S(N)2-Michael addition reaction
Bunce, Richard A.,Allison, Jeffrey C.
, p. 2175 - 2186 (2007/10/03)
A tandem S(N)2-Michael addition sequence has been developed for the preparation of N-(4-methylbenzenesulfonyl)- pyrrolidines and piperidines bearing functionalized side chains at C-2.
