107410-59-3

Basic information

• Product Name: 4-METHYL-N-([(4-NITROPHENYL)AMINO]CARBONYL)BENZENESULFONAMIDE
• Synonyms: 4-METHYL-N-([(4-NITROPHENYL)AMINO]CARBONYL)BENZENESULFONAMIDE;DASU-01
• CAS NO: 107410-59-3
• Molecular Formula: C₁₄H₁₃N₃O₅S
• Molecular Weight: 335.3351
• Mol File: 107410-59-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.463g/cm³
• Refractive Index: 1.644
• CAS DataBase Reference: 4-METHYL-N-([(4-NITROPHENYL)AMINO]CARBONYL)BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-N-([(4-NITROPHENYL)AMINO]CARBONYL)BENZENESULFONAMIDE(107410-59-3)
• EPA Substance Registry System: 4-METHYL-N-([(4-NITROPHENYL)AMINO]CARBONYL)BENZENESULFONAMIDE(107410-59-3)

Safety Data

• Hazardous Substances Data: 107410-59-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H13N3O5S/c1-10-2-8-13(9-3-10)23(21,22)16-14(18)15-11-4-6-12(7-5-11)17(19)20/h2-9H,1H3,(H2,15,16,18)

Upstream product

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Relevant articles and documents

A sulfonyl urea, sulfonamide ethyl ester preparation method of compound (by machine translation)

The description relates to a compound of formula (I) compound of the preparation method, wherein formula (II) with a compound represented by formula (III) as shown in the catalysis of palladium catalyst, under a carbon monoxide atmosphere, reacts in a solvent to obtain the compound. The invention related to the method of the reaction do not require strict-free conditions, does not need a high pressure carbon monoxide atmosphere, convenient and simple to operate, to a functional group and has very high power density and universality, the catalyst consumption is very small, the cost of reaction is very low, and can be widely used for preparing sulfonyl urea compound. R1 - SO2 - NH - CO - X (R3 )n - R2 (I) R1 - SO2 - R4 (II) HX (R3 )n - R2 (III) wherein X is O or N; n is 0 or 1; when X is when O, n=0; when X is when N, n=1; R1 Selected from aryl, heteroaryl, alkyl, alkenyl or alkynyl; R2 Selected from aryl, heteroaryl, alkyl, alkenyl or alkynyl; R3 Is selected from H, R2 , Or R3 And R2 A ring of connection; R4 For N3 Or a halogen atom; when R4 For nails halogen original, system also comprises a sodium azide. (by machine translation)

Novel agents effective against solid tumors: The diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships

A series of diarylsulfonylureas with exceptionally broad-spectrum activity against syngeneic rodent solid tumors in vivo is described. Their discovery resulted from a program dedicated to in vivo screening for novel oncolytics in solid tumor models, rather than traditional ascites leukemia models. The structures, oral efficacy, side-effect profile, and mechanism of action of these sulfonylureas appear to be distinct from previously known classes of oncolytics. An extensive series of analogues was prepared to probe structure-activity relationships (SAR), with particular focus on the substituent patterns of each aryl domain. Quantitative analysis of these substituent SARs, using the method of cluster significance analysis, showed the lipophilicity of the substituents to be the dominant determinant of activity. One compound from the series, LY186641 (104, sulofenur), has progressed to Phase I clinical trials as an antitumor drug.